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. 2023 Oct 7;9:74. doi: 10.1038/s41522-023-00443-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Observed OTUs, Chao1 and Shannon alpha diversity indexes of bacteria coated with IgA (IgA + ) (P value < 0.05, Wilcoxon rank-sum test) b Taxa-bar plot at phylum level of intestinal bacteria coated with IgA in all experimental groups. c Heatmap representation of IgA coating index (ICI) score and relative abundances of specific bacterial families, genera and species coated with IgA. To calculate the ICI score the relative abundance of the IgA+ fraction was divided by the IgA- fraction. In the ICI score heatmap, dark blue represents the highest ICI value and in the relative abundance heatmap, yellow color shows the highest relative abundance. d, e Differentially abundant OTUs identified through DESeq2 testing (adjusted P < 0.05) between d WT and MCJ-deficient mice gut bacteria coated with IgA in homeostasis (WT_DSSn vs KO_DSSn) and e in intestinal inflammation (WT_DSSp vs KO_DSSp).