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. 2023 Oct 7;13:16950. doi: 10.1038/s41598-023-44039-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selinexor (Sel) significantly increases the cytotoxic effect of bendamustine (Ben), fludarabine (F-ara-A) and idelalisib (Ide) against primary CLL cells at multiple concentrations and time points. Heatmaps show the mean viability (% of AnnV-/PI- CLL cells) for 11 samples of patients with CLL that were co-treated in vitro with selinexor + bendamustine, selinexor + fludarabine and selinexor + idelalisib at specific drug concentrations and time points. Cells highlighted with borders indicate the combinations with a CI < 1 (synergistic). Asterisks indicate the combinations which determined a significant reduction in cell viability compared to both single agents, at the corresponding concentration. ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05.