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. 2023 Oct 7;13:16950. doi: 10.1038/s41598-023-44039-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selinexor (Sel) in combination with acalisib (Aca) is effective in reducing the tumor burden in vivo. Mice transplanted with the Eµ-TCL1-derived leukemia were randomly treated with selinexor and acalisib, used as single agents or in combination, or with a vehicle. A schematic outline of in vivo experiments is depicted in (a). (b) Shows the percentage of leukemic cells (CD5+/B220+ cells) in the spleen of mice transplanted with the Eµ-TCL1-derived leukemia after 2 weeks of treatment. (c) shows the macroscopic view of the spleens from two representative animals for each treatment group, and (d) shows the spleen volume for all treated animals. In (b) and (d) box and whiskers plots represent median values, 25–75% percentiles, and minimum and maximum values for each group; each point represents a single sample. **p < 0.01 and *p < 0.05.