TABLE 4.
Association between ever-use of insecticides and risk of NHL subtypes
| Exposed cases | OR (95% CI) | P-heterogeneitya | |
|---|---|---|---|
| Insecticides, any type | .37 | ||
| CLL | 141 | 0.96 (0.69, 1.33) | |
| DLBCL | 114 | 0.97 (0.73, 1.29) | |
| FL | 123 | 1.30 (0.95, 1.78) | |
| MM | 69 | 0.85 (0.60, 1.21) | |
| OBCL | 93 | 0.99 (0.72, 1.34) | |
| TCL | 25 | 1.46 (0.78, 2.74) | |
|
| |||
| Organochlorine insecticides | .005 | ||
| CLL | 77 | 0.80 (0.58, 1.11) | |
| DLBCL | 53 | 0.93 (0.66, 1.31) | |
| FL | 65 | 1.62 (1.14, 2.31) | |
| MM | 40 | 0.79 (0.52, 1.19) | |
| OBCL | 54 | 0.94 (0.66, 1.34) | |
| TCL | 6 | 0.38 (0.16, 0.94) | |
|
| |||
| DDT | .24 | ||
| CLL | 43 | 0.59 (0.39, 0.89) | |
| DLBCL | 27 | 0.76 (0.48, 1.20) | |
| FL | 34 | 1.00 (0.64, 1.57) | |
| MM | 27 | 1.07 (0.64, 1.81) | |
| OBCL | 30 | 0.78 (0.50, 1.21) | |
|
| |||
| Chlordane | .61 | ||
| CLL | 14 | 0.86 (0.45, 1.65) | |
| DLBCL | 12 | 1.43 (0.73, 2.82) | |
| FL | 16 | 1.48 (0.80, 2.73) | |
| MM | 7 | 1.49 (0.54, 4.13) | |
| OBCL | 9 | 1.47 (0.68, 3.18) | |
|
| |||
| Lindane | .99 | ||
| CLL | 8 | 1.05 (0.46, 2.39) | |
| DLBCL | 5 | 1.23 (0.46, 3.28) | |
| FL | 6 | 1.34 (0.53, 3.37) | |
| OBCL | 6 | 1.31 (0.52, 3.27) | |
|
| |||
| Dieldrin | .85 | ||
| FL | 5 | 1.66 (0.52, 5.28) | |
|
| |||
| Organophosphate insecticides | .06 | ||
| CLL | 120 | 1.28 (0.92, 1.77) | |
| DLBCL | 78 | 1.09 (0.79, 1.51) | |
| FL | 95 | 2.01 (1.41, 2.84) | |
| MM | 44 | 1.06 (0.70, 1.60) | |
| OBCL | 82 | 1.13 (0.82, 1.56) | |
| TCL | 18 | 1.02 (0.52, 2.00) | |
|
| |||
| Malathion | .14 | ||
| CLL | 61 | 0.88 (0.58, 1.32) | |
| DLBCL | 32 | 1.03 (0.65, 1.63) | |
| FL | 54 | 1.72 (1.12, 2.62) | |
| MM | 12 | 1.25 (0.59, 2.68) | |
| OBCL | 27 | 0.87 (0.53, 1.41) | |
| TCL | 9 | 1.06 (0.46, 2.44) | |
|
| |||
| Diazinon | .22 | ||
| CLL | 23 | 1.06 (0.62, 1.82) | |
| DLBCL | 14 | 1.23 (0.66, 2.28) | |
| FL | 29 | 2.05 (1.24, 3.37) | |
| OBCL | 16 | 1.69 (0.92, 3.09) | |
|
| |||
| Parathion | .07 | ||
| CLL | 17 | 1.04 (0.57, 1.92) | |
| DLBCL | 11 | 0.83 (0.41, 1.67) | |
| MM | 15 | 1.20 (0.61, 2.34) | |
| OBCL | 35 | 1.94 (1.20, 3.16) | |
|
| |||
| Chlorpyrifos | .88 | ||
| CLL | 24 | 0.67 (0.40, 1.14) | |
| DLBCL | 12 | 0.87 (0.45, 1.69) | |
| FL | 16 | 0.78 (0.43, 1.42) | |
| OBCL | 11 | 0.90 (0.45, 1.80) | |
| TCL | 5 | 1.35 (0.47, 3.83) | |
|
| |||
| Pyrethroid insecticides | .24 | ||
| CLL | 21 | 0.56 (0.34, 0.95) | |
| DLBCL | 28 | 1.20 (0.76, 1.89) | |
| FL | 18 | 0.70 (0.41, 1.21) | |
| MM | 11 | 0.78 (0.39, 1.56) | |
| OBCL | 21 | 0.99 (0.60, 1.66) | |
|
| |||
| Permethrin | .57 | ||
| CLL | 12 | 0.93 (0.46, 1.88) | |
| DLBCL | 7 | 1.09 (0.47, 2.52) | |
| OBCL | 8 | 1.28 (0.57, 2.85) | |
|
| |||
| Carbamate insecticides | .84 | ||
| CLL | 75 | 1.00 (0.70, 1.43) | |
| DLBCL | 40 | 0.93 (0.62, 1.40) | |
| FL | 49 | 1.05 (0.70, 1.57) | |
| MM | 14 | 1.00 (0.53, 1.87) | |
| OBCL | 48 | 1.24 (0.83, 1.83) | |
| TCL | 14 | 1.45 (0.70, 3.02) | |
|
| |||
| Carbaryl | .03 | ||
| CLL | 41 | 0.83 (0.54, 1.27) | |
| DLBCL | 31 | 1.41 (0.89, 2.26) | |
| FL | 47 | 1.89 (1.23, 2.90) | |
| MM | 8 | 1.13 (0.51, 2.54) | |
| OBCL | 30 | 1.40 (0.87, 2.25) | |
| TCL | 12 | 2.44 (1.13, 5.28) | |
Note: Odds ratios (OR) and 95% confidence intervals (CI) from polytomous logistic regression models, with adjustment for study center, age, gender, socioeconomic status (SES), ever-use of herbicides and other noninsecticide pesticides; results for subtypes with <5 exposed cases not shown.
a
P-value for heterogeneity of the association among subtypes.