TABLE 1.
Outcome on day 3 of AOM caused by penicillin-resistant S. pneumoniae treated with amoxicillin and cefuroxime
| Group | No. of animals | No. (%) of animals with culture-positive ME samples
|
No. (%) of ME culture-positive samples | Bacterial counts (log10 CFUa (mean [SD]) | |
|---|---|---|---|---|---|
| Bilateral | Unilateral | ||||
| Untreated controls | 13 | 11 (84.6) | 1 (7.7) | 23 (88.5) | 2.58 (1.67) |
| Amoxicillin, 5 mg/kg | 12 | 1 (8.3) | 2 (16.6) | 4 (16.7)b | 0.74 (1.16)b |
| Amoxicillin, 20 mg/kg | 12 | 3 (25.0) | 0 (0.0) | 6 (25.0)b | 0.94 (1.31)b |
| Cefuroxime, 5 mg/kg | 13 | 6 (46.2) | 4 (30.8) | 16 (61.5) | 1.25 (1.11)b |
| Cefuroxime, 20 mg/kg | 12 | 4 (33.3) | 4 (33.3) | 12 (50.0)b | 1.88 (1.90) |
a
Values are the mean log10 CFU in 20 μl of washing fluid. Data for culture-negative samples were included in the calculation of means by assuming a value at the detection limit (0.30 log10 CFU).
b
Differences between values for treated animals versus those for untreated control animals were statistically significant.