TABLE 2.
Pharmacokinetic and pharmacodynamic data for amoxicillin and cefuroxime in serum in relation to S. pneumoniae susceptibility
| Antibiotic (dose [mg/kg]) | C15 (μg/ml)a | Half-life (min) | C15/MIC | Time above MIC (min [% dose interval]) | AUC/ MIC |
|---|---|---|---|---|---|
| Amoxicillin (5) | 12.2 ± 2.8 | 18.0 | 12.2 | 78 (16.25) | 10.5 |
| Amoxicillin (20) | 35.4 ± 10.0 | 20.7 | 35.4 | 108 (22.50) | 30.5 |
| Cefuroxime (5) | 10.1 ± 2.1 | 16.0 | 2.5 | 36 (7.50) | 2.8 |
| Cefuroxime (20) | 23.3 ± 8.8 | 17.8 | 5.8 | 55 (11.50) | 4.8 |
a
C15, means ± standard deviation concentrations in six animals measured 15 min after the administration of each antibiotic at each dose.