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a) Tables showing base editing outcomes with >5% allele frequency from treatment of DNMT3AWT reporter cells with single missense sgRNAs (See Figure S5 for DNMT3AWT/R882H cell line). Analysis performed with CRISPResso222.
b) Scheme showing genomic DNA and cDNA sequencing of DNMT3AWT reporter cells treated with sgIntron-1. (See Figure S5 for DNMT3AWT/R882H cell line).
c) PyMOL model showing location of D618_K621del (PDB ID 4u7p)10.
