FIG. 1.

Concentration-time profiles under in vitro conditions following bolus dosing with tobramycin (i) and bacterial colony counts (ii) for the P. aeruginosa reference strain ATCC 27853 when exposed to postdistribution peak concentrations of 8 mg/liter (•) and 10 mg/liter (○) (a) and for a clinical isolate of P. aeruginosa when exposed to postdistribution peak concentrations of 18 mg/liter (▴) and 20 mg/liter (▵) (b). A bolus control (— [no antibiotic]) was run in parallel for both isolates. For all studies, n = 6.