TABLE 1.

Summary of results for P. aeruginosa reference strain ATCC 27853^a

Tobramycin profile	Cmax (mg/liter)	AUC0–48.5 h (mg · h/liter)	Bacterial counts (log10 CFU/ml) atb:
			0 h	0.5 h	2.5 h	10.5 h	24.5 h	48.5 h
Postdistribution peak (mg/liter) of complete bolus
0 (control)	0	0	5.86 ± 0.53	5.00 ± 0.24	5.71 ± 0.44	7.83 ± 0.60	8.78 ± 0.52	9.16 ± 0.37
8	27.84 ± 0.74	35.90 ± 1.69	6.01 ± 0.19	2.22 ± 1.28*	0.22 ± 0.53*	0.22 ± 0.53*	3.61 ± 1.00*	8.40 ± 0.78
10	35.53 ± 5.06	42.29 ± 3.96	6.01 ± 0.16	0.73 ± 0.33†	NGD*c	NGD*	NGD†	NGD†
Postdistribution peak of 8 mg/liter to 8.5 h and then reconstituted to (mg/liter):
Control (no antibiotic)	0	0	5.89 ± 0.02	5.29 ± 0.11	5.64 ± 0.36	8.02 ± 0.02	9.08 ± 0.03	9.13 ± 0.02
0	27.31 ± 0.42	30.07 ± 0.32	5.89 ± 0.04	0.92 ± 0.72*	NGD*	NGD*	6.99 ± 0.75	8.93 ± 0.04
0.2	26.42 ± 1.5	32.92 ± 0.38	5.88 ± 0.03	0.92 ± 0.72*	NGD*	NGD*	6.97 ± 0.06	8.93 ± 0.03
0.4	26.99 ± 1.31	35.91 ± 0.94	5.89 ± 0.03	0.92 ± 0.72*	NGD*	NGD*	6.14 ± 0.54*	8.93 ± 0.05
0.6	27.66 ± 0.60	38.87 ± 0.67	5.89 ± 0.03	0.70 ± 0.77*	NGD*	NGD*	3.88 ± 3.06‡	5.97 ± 4.62
0.8	27.39 ± 1.11	41.51 ± 0.56	5.89 ± 0.03	0.65 ± 0.71*	NGD*	NGD*	NGD‡	NGD‡
1.0	27.46 ± 1.13	44.66 ± 0.54	5.90 ± 0.02	0.70 ± 0.77*	NGD*	NGD*	NGD‡	NGD‡

^aFor all groups, values are means ± standard deviations (n = 6). 

^b*, significantly different from control (P < 0.001); †, significantly different from all other exposures (P < 0.001). ‡, Significantly different from other exposures, including control (P < 0.001). 

^cNGD, no growth defect.