TABLE 2.

Summary of results for the clinical isolate of P. aeruginosa^a

Tobramycin profile	Cmax (mg/liter)	AUC0–48.5 h (mg · h/liter)	Bacterial counts (log10 CFU/ml) atb:
			0 h	0.5 h	2.5 h	10.5 h	24.5 h	48.5 h
Postdistribution peak (mg/liter) of complete bolus profile
0 (control)	0	0	5.86 ± 0.06	5.32 ± 0.34	5.31 ± 0.71	8.27 ± 0.39	8.96 ± 0.12	9.05 ± 0.15
18	62.67 ± 1.59	80.36 ± 1.47	5.86 ± 0.08	3.11 ± 0.65*	0.48 ± 0.75*	0.21 ± 0.21*	4.72 ± 0.15*	8.96 ± 0.02
20	69.89 ± 0.36	89.81 ± 0.50	5.90 ± 0.03	2.97 ± 0.07*	NGD*c	NGD*	NGD†	NGD†
Postdistribution peak of 18 mg/liter to 8.5 h and then reconstituted to (mg/liter):
Control (no antibiotic)	0	0	5.87 ± 0.04	5.41 ± 0.28	5.56 ± 0.43	7.98 ± 0.07	9.02 ± 0.07	9.15 ± 0.6
0	63.33 ± 1.66	69.99 ± 1.41	5.90 ± 0.04	3.21 ± 0.32*	0.70 ± 0.77*	NGD*	6.15 ± 0.79*	8.95 ± 0.03
0.2	61.23 ± 2.61	71.59 ± 1.46	5.90 ± 0.05	3.21 ± 0.23*	0.65 ± 0.71*	NGD*	6.14 ± 0.79*	8.94 ± 0.02
0.4	62.38 ± 0.81	75.45 ± 0.34	5.89 ± 0.04	3.18 ± 0.27*	0.43 ± 0.67*	NGD*	5.69 ± 1.56*	8.94 ± 0.02
0.6	62.30 ± 1.55	79.15 ± 0.77	5.92 ± 0.05	3.07 ± 0.43*	0.43 ± 0.67*	NGD*	5.08 ± 1.95*	8.95 ± 0.03
0.8	62.38 ± 0.68	81.31 ± 0.82	5.89 ± 0.05	3.24 ± 0.25*	0.43 ± 0.67*	NGD*	2.05 ± 1.84‡	5.96 ± 4.62
1.0	62.80 ± 0.31	84.44 ± 0.33	5.88 ± 0.02	3.16 ± 0.29*	0.22 ± 0.53*	NGD*	NGD‡	NGD‡
1.2	63.05 ± 0.29	87.49 ± 0.61	5.89 ± 0.03	3.11 ± 0.23*	NGD*	NGD*	NGD‡	NGD‡

^aFor all groups, values are means ± standard deviations (n = 6). 

^b*, significantly different from control (P < 0.001); †, significantly different from all other exposures (P < 0.001); ‡, significantly different from other exposures (P < 0.001). 

^cNGD, no growth detected.