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. Author manuscript; available in PMC: 2023 Oct 8.
Published in final edited form as: Nature. 2021 May 19;594(7863):398–402. doi: 10.1038/s41586-021-03552-w

Extended Data Figure 9. rs7795896 affects CFTR expression levels in ductal cells.

Extended Data Figure 9.

(a) Bayesian colocalization of T1D signal and CFTR pancreas eQTL. Variants in the T1D credible set are circled. (b) Expression of pancreatic cell type marker genes from scRNA-seq. (c) Proportions of selected pancreatic cell types estimated by MuSiC for 220 bulk pancreas RNA-seq samples from the GTEx v7 release using single cell expression profiles. (d) -log10 transformed two-sided uncorrected p-values from linear regression interaction between dosage and cell type proportion for the CFTR pancreas eQTL.