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. 2023 Oct 9;8:385. doi: 10.1038/s41392-023-01631-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — ACE2-spike complex is degraded by clathrin-mediated endocytosis and PAK1-mediated cytoskeleton rearrangement. Full-length spike protein without ACE2 binding is selectively cleaved into S1 and S2 subunits in a lysosomal-dependent manner. Viral entry can be inhibited by CK2 or PAK1 inhibitors