Table 3.
Comorbidities and operation-related characteristics associated with reoperation in univariate and multivariate analyses in the matched cohort.
| Variables | univariate analysis |
multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Smoking history (yes/no) | 3.234 | 2.424–4.316 | <0.001 | 2.900 | 2.100–4.006 | <0.001 |
| Induction therapy (yes/no) | 0.547 | 0.245–1.222 | 0.141 | |||
| Pulmonary tuberculosis history (yes/no) | 2.811 | 1.747–4.520 | <0.001 | 2.291 | 1.331–3.945 | 0.003 |
| Anticoagulant therapy (yes/no) | 0.750 | 0.464–1.211 | 0.239 | |||
| Anemia (yes/no) | 0.599 | 0.303–1.184 | 0.140 | |||
| Elevated creatinine (yes/no) | 0.564 | 0.196–1.624 | 0.289 | |||
| Elevated D-dimer (yes/no) | 3.308 | 2.377–4.603 | <0.001 | 3.465 | 2.373–5.058 | <0.001 |
| CCI score (≥2/<2) | 0.955 | 0.710–1.285 | 0.763 | |||
| ASA PS score (≥3/<3) | 1.185 | 0.872–1.611 | 0.277 | |||
| Surgery periods (night-time/working hours) | 1.814 | 0.972–3.387 | 0.061 | |||
| Pleural adhesion (yes/no) | 2.056 | 1.426–2.964 | <0.001 | 1.904 | 1.249–2.904 | 0.003 |
| Nodal dissection | ||||||
| No dissection | Ref | Ref | ||||
| Hilar | 1.178 | 0.692–2.005 | 0.547 | 0.908 | 0.494–1.667 | 0.755 |
| Mediastinal, systematic or selective | 2.480 | 1.581–3.890 | <0.001 | 1.625 | 0.920–2.870 | 0.095 |
| Length of operation (>2 h/≤2 h) | 1.470 | 1.111–1.946 | 0.007 | 0.735 | 0.523–1.032 | 0.075 |
| Blood loss (>100 mL/≤100 mL) | 2.037 | 1.449–2.865 | <0.001 | 0.988 | 0.652–1.497 | 0.953 |
| Blood transfusion (yes/no) | 0.988 | 0.945–1.034 | 0.610 | |||
| Maximal specimen diameter (>10 cm/≤10 cm) | 2.241 | 1.576–3.186 | <0.001 | 1.160 | 0.741–1.816 | 0.516 |
| Number of drainage tubes (2/1) | 2.027 | 1.529–2.687 | <0.001 | 1.457 | 1.043–2.035 | 0.027 |
| Postoperative complications (yes/no) | 5.601 | 4.052–7.742 | <0.001 | 4.649 | 3.233–6.687 | <0.001 |
CCI: Charlson Comorbidity Index; ASA PS: American Society of Anesthesiologists Physical Status.