Table 1.
Gene set enrichment analysis (GSEA) for hallmarks commonly enriched in PF-429242-treated PLC5 and HepG2 cells
| Hallmark | No. of Genes in Pathway | No. of Pathway Genes Differentially Expressed (% of Total) | NES | p Value | FDR |
|---|---|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 74 | 30 (41%) | -1.95 | < 0.001 | < 0.001 |
| E2F_TARGETS | 200 | 164 (82%) | -1.81 | < 0.001 | < 0.001 |
| G2M_CHECKPOINT | 200 | 134 (67%) | -1.72 | < 0.001 | < 0.001 |
| MITOTIC_SPINDLE | 199 | 128 (64%) | -1.64 | < 0.001 | 0.001 |
| MYC_TARGETS_V1 | 200 | 149 (75%) | -1.59 | < 0.001 | 0.002 |
| OXIDATIVE_PHOSPHORYLATION | 200 | 161 (81%) | -1.56 | < 0.001 | 0.003 |
| PROTEIN_SECRETION | 96 | 76 (79%) | -1.53 | 0.001 | 0.004 |
| DNA_REPAIR | 150 | 103 (69%) | -1.51 | < 0.001 | 0.006 |
| FATTY_ACID_METABOLISM | 158 | 102 (65%) | -1.46 | 0.001 | 0.015 |
| MTORC1_SIGNALING | 200 | 111 (56%) | -1.45 | 0.002 | 0.018 |
Top-10 enriched hallmarks were shown. NES, normalized enrichment score; FDR, false-discovery rate.