TABLE 3.
The effect of losartan on serum urate.
| Mean (SE) | Placebo or losartan versus baseline, mean (95% CI) | Losartan versus placebo, mean (95% CI) | P | |
|---|---|---|---|---|
| Overall, N = 55 (161 measurements) * | ||||
| Baseline | 5.2 (0.2) | Referent | – | – |
| Placebo | 5.0 (0.1) | −0.17 (−0.35, 0.00) | Referent | Referent |
| Losartan | 4.8 (0.1) | −0.40 (−0.60, −0.20) | −0.23 (−0.40, −0.05) | 0.011 |
| Baseline serum urate < 6 mg/dL, N = 39 (115 measurements) | ||||
| Baseline | 4.6 (0.1) | Referent | – | – |
| Placebo | 4.5 (0.1) | −0.06 (−0.26, 0.13) | Referent | Referent |
| Losartan | 4.4 (0.1) | −0.22 (−0.44, 0.00) | −0.16 (−0.33, 0.02) | 0.082 |
| Baseline serum urate ≥6 mg/dL, N = 15 (44 measurements) | ||||
| Baseline | 6.7 (0.1) | Referent | – | – |
| Placebo | 6.3 (0.2) | −0.46 (−0.80, −0.12) | Referent | Referent |
| Losartan | 5.9 (0.2) | −0.85 (−1.21, −0.50) | −0.39 (−0.84, 0.05) | 0.081 |
Note: 1 participant did not have a baseline serum urate measurement and thus was excluded from the stratified analysis.
Since the losartan and placebo comparison relied on end of period measurements all 55 were included in the overall comparison.
The P‐value for an interaction between diet and losartan was 0.72.
*
Test of interaction for losartan versus placebo was 0.31.