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. 2023 Sep 11;25(10):915–922. doi: 10.1111/jch.14721

TABLE 4.

Combined effects of dietary assignment and losartan on serum urate.

Baseline, mean (SE) End of period, mean (SE) Change from baseline, mean (95% CI) DASH‐Losartan versus control‐placebo, mean (95% CI) P
Overall, N = 55 (107 measurements)
Control‐placebo, N = 28 5.36 (0.22) 5.19 (0.22) −0.16 (−0.40, 0.07) Referent Referent
DASH‐Losartan, N = 27 5.00 (0.23) 4.56 (0.20) −0.44 (−0.73, −0.15) −0.28 (−0.65, 0.10) 0.15
Baseline serum urate < 6 mg/dL, N = 39 (77 measurements)
Control‐Placebo, N = 18 4.68 (0.17) 4.62 (0.19) −0.05 (−0.35, 0.24) Referent Referent
DASH‐Losartan, N = 21 4.53 (0.19) 4.30 (0.19) −0.22 (−0.48, 0.03) −0.17 (−0.56, 0.22) 0.39
Baseline serum urate ≥6 mg/dL, N = 15 (29 measurements)
Control‐Placebo, N = 9 6.74 (0.14) 6.38 (0.26) −0.37 (−0.76, 0.02) Referent Referent
DASH‐Losartan, N = 6 6.67 (0.28) 5.40 (0.47) −1.27 (−1.94, −0.59) ‐0.90 (−1.68, −0.12) 0.024

The P‐value for an interaction between diet and losartan overall was 0.72.

The P‐value for an interaction across strata of baseline serum urate using a Wald test was 0.015.