TABLE 1.

MICs of erythromycin and HMR 3004 for enterococci and streptococci

Species (no. of strains)	MIC (μg/ml)
	Erythromycin	HMR 3004	HMR 3004, induceda
Control strains
E. faecalis JH2-2	1	0.03	0.03
E. faecalis JH2-2/pAMβ1	>8,000	32	32
S. agalactiae HM50	0.25	0.03	NDb
S. pneumoniae HM51	0.12	0.03	0.12
Strains inducibly MLSB resistant
Enterococci (11)	8,000	2–16	16–32
Oral streptococci (6)	256–>8,000	0.06–2	4–32
S. agalactiae (6)	16–4,000	0.03–2	0.12–8
S. pneumoniae (12)	128–8,000	<0.01–1	1–4
Strains constitutively MLSB resistant
Enterococci (2)	8,000	32	≥32
S. agalactiae HM1081 (1)	2,000	8	8
S. pneumoniae (2)	8,000	4	4

^aInduced, the MICs of RU 640004 were determined after induction with 0.1 or 1 μg of erythromycin per ml. 

^bND, not done.