Table 3.
Adverse events
| Toxicities∗ | Any grade |
Grade ≥3 |
||
|---|---|---|---|---|
| No | Percentage (%) | No | Percentage (%) | |
| Hematologic | ||||
| Thrombocytopenia | 27 | 93 | 10 | 34 |
| Anemia | 26 | 90 | 8 | 28 |
| Neutropenia | 20 | 69 | 13 | 45 |
| Infectious | ||||
| URI | 5 | 17 | 1 | 3 |
| Lung infection | 3 | 10 | 3 | 10 |
| Sepsis | 3 | 10 | 3 | 10 |
| UTI | 3 | 10 | 1 | 3 |
| Cellulitis | 3 | 10 | 1 | 3 |
| Other | ||||
| Hypoalbuminemia | 27 | 93 | 7 | 24 |
| Fatigue | 27 | 93 | 5 | 17 |
| Hyponatremia | 26 | 90 | 13 | 45 |
| Hypertension | 25 | 86 | 11 | 38 |
| Nausea | 23 | 79 | 0 | 0 |
| Hypocalcemia | 22 | 76 | 1 | 3 |
| Constipation | 21 | 72 | 0 | 0 |
| Hypomagnesemia | 20 | 69 | 1 | 3 |
| Hypokalemia | 18 | 62 | 4 | 14 |
| Anorexia | 16 | 55 | 1 | 3 |
| Cough | 16 | 55 | 0 | 0 |
| Hyperglycemia | 15 | 52 | 4 | 14 |
| Fever | 15 | 52 | 2 | 7 |
| Blood bilirubin increased | 14 | 48 | 4 | 14 |
| Diarrhea | 14 | 48 | 1 | 3 |
| Edema | 14 | 48 | 1 | 3 |
| Dyspnea | 13 | 45 | 2 | 7 |
| Weight loss | 13 | 45 | 1 | 3 |
| AST increased | 12 | 41 | 2 | 7 |
| Dysgeusia | 12 | 41 | 0 | 0 |
| Creatinine increased | 12 | 41 | 1 | 3 |
| Pruritis | 11 | 38 | 2 | 7 |
| Abdominal pain | 10 | 34 | 1 | 3 |
| Reflux | 10 | 34 | 0 | 0 |
| Dizziness | 9 | 31 | 0 | 0 |
| Headache | 9 | 31 | 0 | 0 |
| Vomiting | 9 | 31 | 0 | 0 |
| ALT increased | 8 | 28 | 1 | 3 |
| Hypotension | 7 | 24 | 1 | 3 |
| Rash | 7 | 24 | 1 | 3 |
| Hypothyroidism | 5 | 17 | 0 | 0 |
| Dehydration | 4 | 14 | 3 | 10 |
| Hypoglycemia | 4 | 14 | 0 | 0 |
| Mucositis | 4 | 14 | 0 | 0 |
| Sinus bradycardia | 4 | 14 | 0 | 0 |
| Colitis | 3 | 10 | 2 | 7 |
| Arthralgia | 3 | 10 | 1 | 3 |
| Atrial fibrillation | 3 | 10 | 1 | 3 |
| Confusion | 3 | 10 | 1 | 3 |
| Hypercalcemia | 3 | 10 | 0 | 0 |
| Hyperkalemia | 3 | 10 | 0 | 0 |
| Hypermagnesemia | 3 | 10 | 0 | 0 |
| Hypernatremia | 3 | 10 | 0 | 0 |
AST, aspartate transaminase; URI, upper respiratory infection; UTI, urinary track infection.
∗
Nonhematologic AEs occurring in >10% patients.