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Change in the time-resolved impact fractions of parPARP, pATM, and IKKγ at 15 Gy and ATM inhibition
(A) Simulated time course of the flux of signalosome formation and area under the curve (auc) upon 15 Gy and inhibition of ATM activation by 90%. The inhibition is simulated by a simultaneous decrease in parameters k3 and k5 by 90%.
(B) Trajectories of parPARP, pATM, and IKKγ are colored based on the corresponding time-resolved impact fraction ω.
