TABLE 1.
Pharmacokinetics of moxifloxacin and ceftriaxone in serum and CSF and leukocyte density and protein content in CSF during experimental meningitis caused by S. pneumoniae
| Antibiotic | Dosage (mg/kg/h) | No. of rabbits | Mean ± SD concn (μg/ml)
|
Mean ± SD concn ratio at 24 ha | Median (25th/75th percentile) leukocyte counts in CSF
|
Mean ± SD protein content (mg/liter) in CSF
|
|||
|---|---|---|---|---|---|---|---|---|---|
| Serum | CSF | 12h | 24h | 12h | 24h | ||||
| Ceftriaxone | 10 | 10 | 159.6 ± 48.4 | 7.1 ± 3.4 | 0.06 ± 0.03 | 1,123 (341/2,125) | 14,037 (7,547/21,078) | 862 ± 1,102 | 4,159 ± 1,881 |
| Moxifloxacin | 2.5 | 6 | 3.3 ± 0.3 | 1.9 ± 0.2 | 0.36 ± 0.04 | 3,499 (1,371/6,592) | 11,258 (8,748/17,110) | 957 ± 403 | 3,904 ± 1,849 |
| Moxifloxacin | 10 | 10 | 10.4 ± 3.4 | 3.8 ± 1.2 | 0.44 ± 0.08 | 3,147 (771/6,358) | 7,210 (2,799/13,555) | 1,533 ± 1,170 | 4,902 ± 3,971 |
| Moxifloxacin | 20 | 4 | 19.8 ± 5.1 | 8.5 ± 3.2 | 0.47 ± 0.08 | 6,262 (4,675/9,366) | 4,560 (3,523/6,640) | 1,063 ± 632 | 11,875 ± 11,803 |
| Moxifloxacin + dexamethasone | 10 | 6 | 12.3 ± 4.2 | 3.3 ± 0.6 | 0.34 ± 0.15 | 1,975 (604/7,999) | 4,886 (2,528/5,823) | 603 ± 279 | 2,119 ± 891 |
a
Ratio of concentration in CSF to concentration in serum.