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. 2023 Sep 15;77:101808. doi: 10.1016/j.molmet.2023.101808

Figure 5.

Figure 5

N-acetyl-l-cysteine still protects in MPC2/ALT2 double-knockout mice. Male liver-specific MPC2/ALT2 DKO mice and WT littermates 10–16 weeks old were treated with 300 mg/kg followed by 318 mg/kg NAC 2 h later. Serum and liver tissue were collected at 6 h post-APAP. (A) Serum ALT was measured. (B) Total glutathione was measured in liver tissue homogenates. Means were compared using a one-way ANOVA with post-hoc Tukey's test. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001. Bars represent mean ± SE of n = 5 mice per group for WT Veh and DKO Veh. N = 6 mice per group for WT NAC and DKO NAC.