Table 2.

Imaging features among different CEUS LI-RADS categories

Variable	LI-RADS categories
	all (n = 293)	LR-4 (n = 16)	LR-5 (n = 225)	LR-M (n = 52)	p value
CEUS
Enhancement patterns of arterial phase
APHE in whole	242 (82.6)	9 (56.2)	199 (88.4)	34 (65.4)	<0.001
APHE in part	38 (13.0)	1 (6.3)	26 (11.6)	11 (21.2)
Iso-enhancement	8 (2.0)	6 (37.5)	0	0
Rim APHE	7 (2.4)	0	0	7 (13.4)
Enhanced uniformity
Yes	235 (80.2)	13 (81.2)	189 (84.0)	33 (63.5)	0.004
No	58 (19.8)	3 (18.8)	36 (16.0)	19 (36.5)
Necrosis in tumor
Yes	35 (11.9)	1 (6.2)	20 (8.9)	14 (26.9)	0.001
No	258 (88.1)	15 (93.8)	205 (91.1)	38 (73.1)
Feeding artery
Yes	260 (88.7)	12 (75.0)	200 (88.9)	48 (92.3)	0.158
No	33 (11.3)	4 (25.0)	25 (11.1)	4 (7.7)
Intratumoral artery
Yes	104 (35.5)	6 (37.5)	79 (35.1)	19 (36.5)	0.967
No	189 (64.5)	10 (62.5)	146 (64.9)	33 (63.5)
Onset of washout
<45 s	10 (3.4)	0	0	10 (19.2)	<0.001
45–60 s	40 (13.7)	0	0	40 (76.9)
60–120 s	151 (51.5)	5 (31.3)	144 (64.0)	2 (3.9)
>120 s	82 (28.0)	1 (6.2)	81 (36.0)	0
No washout	10 (3.4)	10 (62.5)	0	0
Degree of washout
Mild/moderate	266 (94.0)	6 (100)	225 (100)	35 (67.3)	<0.001
Marked	17 (6.0)	0	0	17 (32.7)
B-mode
Echogenicity
Hypo-	107 (36.5)	6 (37.5)	87 (38.7)	14 (26.9)	0.212
Iso-	67 (22.9)	5 (31.3)	54 (24.0)	8 (15.4)
Hyper-	68 (23.2)	3 (18.7)	47 (20.9)	18 (34.6)
Mix-	51 (17.4)	2 (12.5)	37 (16.4)	12 (23.1)
Halo
Yes	104 (35.5)	4 (25.0)	80 (35.6)	20 (38.5)	0.616
No	189 (64.5)	12 (75.0)	145 (64.4)	32 (61.5)
Intratumoral vascularity
Yes	149 (50.9)	4 (25.0)	117 (52.0)	28 (53.8)	0.101
No	144 (49.1)	12 (75.0)	108 (48.0)	24 (46.2)