Table 3.
Mean laboratory values in dyspneic older ED patients diagnosed with and without pneumonia. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) reported for laboratory studies that are significant or trend towards significance. Data are presented as mean and 95% confidence interval.
| Pneumonia (n=10) | No pneumonia (n=69) | p-value | Sensitivity | Specificity | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Leukocyte count (K/uL)1 | 11.5 | (7.0–16.1) | 7.8 | (7.1–8.4) | <0.01 | 50.0% | 89.9% |
| Procalcitonin (ng/mL) | 0.18 | (0.03–0.33) | 0.11 | (0.05–0.17) | 0.42 | ||
| HNP1–3 (pg/mL) | 224.1 | (205.1–243.1) | 387.6 | (210.2–564.9) | 0.25 | ||
| LL-37 (ng/mL) | 3.1 | (1.8–4.3) | 3.1 | (2.1–4.0) | 0.61 | ||
| DEFB2 (pg/mL)2 | 1,072.1 | (470.8–1,673.3) | 608.9 | (432.6–786.2) | 0.09 | 80.0% | 44.9% |
| DEFA5 (pg/mL)3 | 428.7 | (295.3–562.1) | 342.0 | (316.9–367.1) | 0.08 | 80.0% | 44.9% |
|
| |||||||
| Pneumonia (n=10) | No pneumonia (n=69) | p-value | |||||
|
| |||||||
| Leukocyte count (K/uL) | 11.5 | (7.0–16.1) | 7.8 | (7.1–8.4) | <0.01 | ||
| Procalcitonin (ng/mL) | 0.18 | (0.03–0.33) | 0.11 | (0.05–0.17) | 0.42 | ||
| HNP1–3 (pg/mL) | 224.1 | (205.1–243.1) | 387.6 | (210.2–564.9) | 0.25 | ||
| LL-37 (ng/mL) | 3.1 | (1.8–4.3) | 3.1 | (2.1–4.0) | 0.61 | ||
| DEFB2 (pg/mL) | 1,072.1 | (470.8–1,673.3) | 608.9 | (432.6–786.2) | 0.09 | ||
| DEFA5 (pg/mL) | 428.7 | (295.3–562.1) | 342.0 | (316.9–367.1) | 0.08 | ||
|
| |||||||
| Sensitivity | Specificity | NPV | PPV | ||||
| Leukocyte count (K/uL)1 | 50.0% | 89.9% | 92.5% | 41.7% | |||
| DEFB2 (pg/mL)2 | 80.0% | 44.9% | 93.9% | 17.4% | |||
| DEFA5 (pg/mL)3 | 80.0% | 44.9% | 91.2% | 15.6% | |||
1
Cut point 10.10 for males, 11.19 for females
2
Cut point 266.4
3
Cut point 313.6