Public health measure 3: Quarantine | Study features | Outcomes and findings | Translational steps |
Systematic reviews, guidelines | |||
Brooks 2020*^ (rapid review) Mapping to: Acceptability, feasibility and related factors |
Outcomes and aim: Psychological impact of quarantine and mitigation Inclusion and exclusion criteria: Included: participants entering quarantine of at least 24 hours, outside hospital setting Types of study and data: Rapid SR; 24 included studies. Surveys (cross‐sectional, longitudinal, other), observations; focus groups and interviews Included disease(s): SARS (14 studies), EVD (5), H1N1 (2), MERS (2), equine influenza (1) Countries included: Taiwan (2), Canada (8), Australia (2), Liberia (2), South Korea (2), China (4), Canada and USA (1), Sierra Leone, Senegal, Hong Kong Quality assessment: 4/9 AMSTAR rating% Funding source: The research was funded by the National Institute for Health Research (NIHR) Health Protection Research Unit in Emergency Preparedness and Response at King’s College London, in partnership with Public Health England, and in collaboration with the University of East Anglia and Newcastle University. |
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Recommendations: Quarantine people for the shortest possible time (based on scientific evidence of incubation times, rather than indefinitely). Provide information (rationale and guidelines for quarantine – what is happening, and why) through clear, consistent communication. Provide adequate supplies, both general and medical. Reduce boredom by providing meaningful activities and ensuring communication with social networks (including support lines). Provide clear lines of communication for those in quarantine, should they develop symptoms (e.g. phone line/online service staffed by health professionals). Consider health professionals as special cases, needing support from both immediate colleagues and organisationally. Public health messages should reinforce the protective, altruistic choice of quarantine/self‐isolation. |
Communication purpose: Factors identified here may inform strategies for communicating with and supporting people in quarantine/self‐isolation, in particular to identify information required and channels of communication that may best support people in order to minimise psychological impacts of quarantine. Related to review questions: Findings suggest that lack of information, communication and support may have negative psychological effects that influence acceptability and related factors. |
Gomez‐Duran 2020#^ Citation type: SR (rapid) Public health measure: Quarantine Mapping to: Acceptability Mapping to: Theme 3: support for individual and population behavioural changes Theme 6: distancing measures in schools and workplaces |
Overview and aim: To investigate the psychological effects of quarantine on healthcare workers (HCWs) in order to better understand the needs and concerns of this group Type of study and data: SR; N = 12 studies; qualitative (3 studies) and quantitative (7 cross‐sectional, 1 observational, 1 prospective). 10/12 related to SARS outbreak, 2/12 EVD Inclusion and exclusion criteria: Included: primary research on HCWs in quarantine; report mental health/psychological outcomes related to quarantine; published in peer‐reviewed journal. No timing or language restrictions Excluded: not primary research, HCWs in quarantine or psychological outcomes Participant features and numbers, sampling details: Sample sizes ranged from 10 to approximately 270 HCWs, often as part of larger sample. Few details of professional role or demographics. Quarantine duration 10 days to 3 weeks Included disease(s): Outbreaks prior to COVID‐19 (included: SARS and EVD) Timing: Search for evidence April 2020 Countries included: Canada (5 studies), China (3), Taiwan (2), Senegal (1), Sweden (1) Most (8/12) studies in high‐income brackets; also middle income (upper‐middle China lower‐middle Senegal) Intervention or phenomenon of interest: Psychological impact of quarantine in HCWs, potential needs and concerns Quality assessment: AMSTAR 5/11 [1. No protocol; 4. Published papers only; 5. No excluded studies list provided; 8. Quality assessed but not closely integrated to findings; 10. no publication bias assessment; 11. no COI for included studies] Funding source: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not‐for‐profit sectors. |
Reported on: Mental health issues:
Emotional responses:
Inadequate information:
Financial losses:
Stigma:
Recommendations: Quarantine of HCWs leads to considerable psychological distress, mental health problems, isolation and financial losses, as well as stigma from various sources. Additionally, HCWs experience conflict between professional and family (personal) roles, with many expressing concerns about the impact of quarantine on their family’s safety and well‐being, especially their children. Psychological support for HCWs in and following quarantine is needed; without this, poor psychological effects can persist for years after the outbreak and quarantine period. Quarantine may present the opportunity to deliver psychological support to HCWs who would otherwise be too busy working to engage with these services. Clear, unambiguous information from health authorities and the media are needed to convey accurate information to the public about quarantined HCWs; while accurate, timely information to HCWs undergoing quarantine would assist them to manage uncertainty and consequent effects on their own health and well‐being. Concerns about their family was a common issue for HCWs; providing suitable accommodation to HCWs (outside the family home) may help to lessen the risk to families and alleviate HCWs’ concerns about infection risk. |
Communication purpose: Findings may be useful in developing public communication strategies to convey accurate information about quarantine and associated risks. Findings may also inform communication strategies for HCWs in quarantine and help to identify better mechanisms of support. Related to review questions: High levels of distress, fear of infection and poor psychological outcomes are common in the public undergoing quarantine. These same outcomes are also prevalent in HCWs in quarantine, with additional complexity because of their dual role as HCW and family member. Such issues highlight the need for better support and information for HCWs in quarantine. Providing clear, accurate and timely information about disease and quarantine risks to both those undergoing quarantine and the general public may help to mitigate some of the poor outcomes people commonly experience. It may also serve to diminish stigma associated with quarantine by members of the general public and others. Psychological support is needed to help to address some of the poor outcomes experienced by HCWs in quarantine, some of which may be long‐lasting. Quarantine may provide a window of opportunity to intervene and provide support, as otherwise HCWs may be too busy during a disease outbreak. Support for HCWs might also include financial compensation, as financial losses are commonly reported and may increase psychological distress. |
Lin 2014* (SR) Mapping to: Adherence Relevant to general PD measures (particularly crowd avoidance/individual PD) |
Outcomes and aim: Identification of factors associated with communication inequalities during H1N1 pandemic Inclusion and exclusion criteria: Included: communication with public during H1N1 pandemic, empirical data Excluded: not published in English, French, Italian, Spanish, Chinese or Portuguese; focused on communication between agencies or health professionals, on development of telecommunication strategies, or on public health surveillance or epidemiology; or not related specifically to the H1N1 pandemic in 2009 Type of study and data: SR; 118 included studies Population‐based studies (92/118), studies on information environment; primarily survey‐based (cross‐sectional or other), some interview or focus group‐based Countries included: USA, China, UK main countries Quality assessment: 5/11 AMSTAR rating Funding source: We acknowledge funding support from the U.S. Centers for Disease Control and Prevention (CDC) grant number 5PO1TP000307‐05 Supplement. |
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Recommendations:
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Communication purpose: Results may be useful for those planning communication campaigns and seeking to reduce communication inequalities across communities. Factors identified may be useful for developing targeted messages to vulnerable groups, and may inform the medium of communication, as well as the sources of information drawn upon. Related to review questions: Findings suggest that several factors influence community awareness of public health messages related to a pandemic, and this in turn influences compliance with recommended protective measures, including physical distancing measures. Communications intended to inform populations about pandemic disease and preventive measures need to take account of such factors to ensure that communication is as equitable and has as much reach within communities as is possible, in order to mount a consistent preventive response to a pandemic. |
Sopory 2021#^ Citation type: SR (QES) Public health measure: Quarantine Mapping to: Acceptability adherence, Mapping to: Theme 1: features of public communication: content, timing and duration, and delivery Theme 2: recipients of public communication: audience, setting and equity Theme 3: support for individual and population behavioural changes |
Overview and aim: To examine adherence to quarantine by exploring strategies to influence adherence, identifying barriers and enablers of acceptance and identifying benefits and harms of quarantine Type of study and data: QES; any primary qualitative research. N = 17 included studies (16 qualitative, 1 mixed‐methods with separate qualitative component) Inclusion and exclusion criteria: Included: Published 2001 onwards, English language; qualitative method. Excluded: Documents (e.g. commentary) Participant features and numbers, sampling details: Quarantined population general public (14 studies), healthcare workers (7). Vulnerable populations addressed 5/16 studies Included disease(s): General infectious disease (1 study), EBV (4), influenza (4), SARS (7) Timing: Published evidence sought 2001 onwards. Event year varied across time period 2003 to 2016. Data collection period was pre‐event (4 studies), post‐real event (10), and during a real event (6). Countries included: Canada (6 studies), United States (4), Australia (1), international (1), Taiwan (1), remote First Nations Canada (2), Africa (Liberia) (1), Senegal (1)) 12/17 conducted in high‐income countries. Authors noted that the synthesis was conducted for the US context, and this may have introduced bias weighted towards understanding the phenomenon for high‐, rather than low‐middle‐ income countries. Intervention or phenomenon of interest: Adherence to quarantine Quality assessment: AMSTAR 8/11 [5. No excluded studies listed; 10. Publication bias not assessed; 11. COI of included studies not reported] Re item 1. No protocol or a priori mentioned in published paper but formed part of a larger evidence synthesis report for National Academy so determined scope is implied 2. Duplicate processes confirmed by author response. 4. Extensive searching including grey literature outlined in accompanying report Funding source: Funding for the review was received by Pradeep Sopory and Julie Novak. The review was commissioned by the National Academies of Sciences, Engineering, and Medicine (National Academies) Committee on Evidence‐Based Practices for Public Health Emergency Preparedness and Response (Contract# 20000010696), which was sponsored by the United States Centers for Disease Control and Prevention (CDC). |
Reported on: 18 synthesised findings were reported. Quarantine adherence (3 major findings, low‐high confidence):
Quarantine adherence facilitators/acceptance (2 main findings, moderate ‐high confidence):
Quarantine acceptance (4 main findings, high confidence). Restrictions may be more acceptable to people undertaking quarantine when there is:
Harms of quarantine restrictions (4 main findings, high confidence):
Quarantine and vulnerable groups (1 finding, high confidence):
Recommendations: Findings were used to develop a conceptual framework, outlining topics for considerations in situations where quarantine may be implemented to curb disease outbreak. These may help to improve acceptance and adherence to quarantine in particular. Findings indicate two major sets of communication activities to be undertaken related to the topics identified: communication within and across agencies and organisations related to the coordination of quarantine activities, and communication of information about quarantine to the general public. Quarantine is controversial and relies on the public understanding the benefits as well as risks and potential harms. These need to be effectively communicated to the public by the agencies involved in planning and implementing the restrictions. When planning and implementing quarantine, vulnerable groups within the population such as the poor or marginalised, may need additional protections. Such groups may be more at risk of harms, or the harms may be more severe – such as financial hardships that are worsened by being required to quarantine, and/or the need to safeguard civil rights of vulnerable groups. |
Communication purpose: Findings may inform development of communication strategies to provide information to the public about quarantine restrictions. Related to review questions: Information about quarantine is important to both the general public and to healthcare workers, and effective communication from agencies, tailored to local context and undertaken co‐operatively with local structures and leadership, is needed to promote acceptance and adherence to quarantine measures. Effective information and communication might best involve two‐way dialogue with the community, happen over the course of the disease outbreak, and involve multiple channels and sources. Information should be clear and accessible, non‐stigmatising or inflammatory, and include a rationale for the quarantine measures as well as information on the process and supports available for people. Recognition of the supports needed for the public undertaking quarantine is needed, alongside particular awareness of heightened risks of harms of quarantine in vulnerable groups is needed. Acceptance of quarantine may be greater, and harms minimised, where people’s needs are met, including financial compensation, food and essential supplies, and social support, and that there is some flexibility in the system to accommodate particular needs. |
Webster 2020#^ (rapid review) Mapping to: Adherence |
Outcome and aim: To identify factors affecting adherence to quarantine during disease outbreaks Inclusion and exclusion criteria: Included: participants entering quarantine of at least 24 hours, outside hospital setting. Studies reporting primary research, published in English or French, reporting factors associated with or reasons for (non)‐adherence outcomes Type of study and data: Rapid SR; 14 included studies. Surveys (cross‐sectional), retrospective cohort, interviews, focus groups Included disease(s): H1N1 (5 studies), EVD (3), SARS (5), mumps (1) Quarantine varied: Home quarantine (up to 14 days), EVD studies included restriction of movements (1 month), check‐ups and social distancing (21 days), state‐enforced home and neighbourhood quarantine (21 days). Countries included: Australia (5), Canada (3), Senegal, Liberia, Sierra Leone, Germany, Taiwan, USA Quality assessment: 5/11 AMSTAR rating Funding source: The research was funded by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emergency Preparedness and Response at King's College London in partnership with Public Health England (PHE), in collaboration with the University of East Anglia and Newcastle University. |
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Recommendations: To increase adherence to quarantine protocols, public health officials should provide:
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Communication purpose: Results may inform decisions about main information messages to communicate to populations and individuals being asked to quarantine. Related to review questions: Findings indicate that several factors influence adherence to quarantine measures. Consideration of these factors should inform public health communications related to quarantine. |
WHO 2021b# Citation type: GL (interim advice) Considerations for quarantine of contacts of COVID-19 cases: WHO interim guidance June 2021 Public health measure: Quarantine Mapping to: Acceptability, adherence Mapping to: Theme 1: features of public communication: content, timing and duration, and delivery Theme 3: support for individual and population behavioural changes Theme 4: community engagement to support communication |
Overview and aim: Updated advice on implementation of quarantine for contacts of COVID‐19 cases, including provision of support for people under quarantine Type of study and data: GL (interim advice); based on review of evidence and informed by experiences from Member States Included disease(s): COVID‐19 Timing: Guidance refers to importance of early communication with the public about quarantine (i.e. prior to implementation), including engagement with communities at early stages to help improve acceptability of quarantine. The importance of communicating with those undertaking quarantine at the beginning of their confinement is also emphasised. Countries included: N/A, developed by WHO, across‐country application Intervention or phenomenon of interest: Quarantine implementation and communication with those involved Quality assessment: AGREE II scope and purpose 63.9%; stakeholder involvement 38.89%; rigour of development 8.3%; clarity of presentation 77.78%; applicability 22.92%; editorial independence 0% Funding source: Not reported |
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Recommendations: People undertaking quarantine need clear, accessible information about why the measure is needed and what is involved, as well as a range of support to enable them to undertake quarantine safely and to adhere to the restrictions during the quarantine period. |
Communication purpose: Guidance may be useful when considering communication with the public and with individuals in relation to quarantine. Related to review questions: Clear communication and information, together with community engagement, are needed prior to implementation of quarantine. This may improve acceptability and adherence to the measures. Provision of the range of supports identified may enable people to adhere to quarantine measures safely and to mitigate the economic and social risks of doing so. |
Primary studies | |||
Zhu 2020# (primary) Mapping to: Uptake. Relevant to general awareness of measures required (crowd avoidance) |
Overview and aim: Public attention to a disease outbreak can be captured by social media posts, where awareness and attentiveness have implications for acceptance and adoption of prevention and control measures. Inclusion and exclusion criteria: Included: randomly sampled accounts of Weiboscope database, a nationally representative sample of the Weibo user population Timing: Between December 31, 2019, and February 12, 2020 Type of study and data: Longitudinal analysis of posts from cohort (52,268 randomly sampled accounts) of Weiboscope database Countries included: China Disease(s) included: Cohort’s posts were searched for COVID‐19‐related keywords and a daily percentage calculated (no. COVID‐related posts/no. total daily posts) Quality assessment: Response rate: + Representativeness: +++ Authors declared no COI; possibility of Internet censorship in China, sample included only one of several social media platforms; paper published (peer reviewed) |
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Recommendations:
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Communication purpose: Might inform decisions about timing of communication of outbreak information to communities and populations, where earlier awareness might promote better engagement with required physical distancing measures. Related to review questions: Findings suggest that lack of outbreak awareness creates missed opportunities for the public to take up preventive and control measures. |