16. Experimental versus placebo: self‐injurious behaviour results that could not be used in the meta‐analysis.
| Study name | Short‐/medium‐/long‐term outcomes | Group 1 sample size | Group 2 sample size | Group 1 results Mean (standard deviation) | Group 2 results Mean (standard deviation) | Other data | Notes |
| Dean 2019 | Short‐term self‐injurious behaviour (N‐acetylcysteine 500 mg/day) |
48 | 50 | 2.2 (2.9) | 1.7 (2.6) | "There were no differences between N‐acetyl cysteine and placebo‐treated groups on any of the outcome measures for either primary or secondary endpoints. There was no significant difference in the number and severity of adverse events between groups" | Skewed |
| Hardan 2012 | Short‐term self‐injurious behaviour (N‐acetylcysteine maz 900 mg/day 3 times daily) | 14 | 15 | 2.2 (2.3) | 3.0 (3.6) | "Compared with placebo, NAC resulted in significant improvements on ABC irritability subscale (F= 6.80; P <.001;d.= 0.96)" | Skewed |
| Hollander 2020a | Short‐term self‐injurious behaviour (Trichuris suis ova, dose of 2500 ova every 2 weeks) | 10 | 10 | −0.37 (2.5) | 0.42 (2.31) | "Trending improvements were observed in irritability using the overall percent change from baseline to endpoint on the Aberrant Behavior Checklist (ABC)–Irritability subscale" | Skewed |
| NAC: N‐acetylcysteine | |||||||