Comparison 6. Atypical vs atypical antipsychotics.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
6.1 Irritability	2	110	Std. Mean Difference (IV, Random, 95% CI)	0.40 [0.02, 0.78]
6.2 Adverse effects: cardiovascular	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6.2.1 Tachycardia	2	120	Risk Ratio (IV, Random, 95% CI)	1.07 [0.16, 7.04]
6.3 Adverse effects: gastrointestinal	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6.3.1 Abdominal pain	1	59	Risk Ratio (IV, Random, 95% CI)	3.10 [0.34, 28.15]
6.3.2 Constipation	2	120	Risk Ratio (IV, Random, 95% CI)	1.30 [0.34, 4.91]
6.3.3 Diarrhoea	1	59	Risk Ratio (IV, Random, 95% CI)	3.10 [0.13, 73.14]
6.3.4 Drooling	2	120	Risk Ratio (IV, Random, 95% CI)	0.72 [0.38, 1.37]
6.3.5 Dry mouth	1	59	Risk Ratio (IV, Random, 95% CI)	5.17 [0.26, 103.21]
6.3.6 Nausea	1	59	Risk Ratio (IV, Random, 95% CI)	0.52 [0.05, 5.40]
6.3.7 Vomiting	2	120	Risk Ratio (IV, Random, 95% CI)	1.61 [0.20, 12.65]
6.4 Adverse effects: metabolic	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6.4.1 Decreased appetite	2	120	Risk Ratio (IV, Random, 95% CI)	1.67 [0.56, 4.96]
6.4.2 Increased appetite	2	120	Risk Ratio (IV, Random, 95% CI)	0.61 [0.15, 2.47]
6.4.3 Weight gain	1	61	Risk Ratio (IV, Random, 95% CI)	0.37 [0.19, 0.70]
6.5 Adverse effects: musculoskeletal	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.5.1 Muscle rigidity	1	61	Risk Ratio (M‐H, Random, 95% CI)	2.91 [0.12, 68.66]
6.6 Adverse effects: neurological	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6.6.1 Agitation	1	61	Risk Ratio (IV, Random, 95% CI)	4.84 [0.24, 96.89]
6.6.2 Difficulty sleeping	1	61	Risk Ratio (IV, Random, 95% CI)	6.78 [0.37, 125.95]
6.6.3 Dizziness	2	120	Risk Ratio (IV, Random, 95% CI)	0.73 [0.10, 5.39]
6.6.4 Fatigue	1	59	Risk Ratio (IV, Random, 95% CI)	1.03 [0.29, 3.75]
6.6.5 Headache	1	61	Risk Ratio (IV, Random, 95% CI)	0.97 [0.06, 14.78]
6.6.6 Nausea	1	61	Risk Ratio (IV, Random, 95% CI)	2.91 [0.12, 68.66]
6.6.7 Nervousness	1	59	Risk Ratio (IV, Random, 95% CI)	2.07 [0.20, 21.60]
6.6.8 Restlessness	2	120	Risk Ratio (IV, Random, 95% CI)	0.44 [0.07, 2.88]
6.6.9 Tremor	1	59	Risk Ratio (IV, Random, 95% CI)	1.55 [0.28, 8.62]
6.6.10 Sedation	1	61	Risk Ratio (IV, Random, 95% CI)	3.39 [0.76, 15.02]
6.6.11 Somnolence	1	61	Risk Ratio (IV, Random, 95% CI)	8.72 [0.49, 155.27]
6.7 Adverse effects: psychological	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.7.1 Depression	1	59	Risk Ratio (M‐H, Random, 95% CI)	0.34 [0.01, 8.13]
6.8 Adverse effects: skin	1		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6.8.1 Rash	1	59	Risk Ratio (IV, Random, 95% CI)	1.03 [0.07, 15.77]
6.9 Adverse effects: urinary	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only
6.9.1 Enuresis	2	120	Risk Ratio (IV, Random, 95% CI)	1.37 [0.04, 53.78]
6.10 Tolerability/acceptability: loss to follow‐up	2		Risk Ratio (IV, Random, 95% CI)	Subtotals only