Jung 2000.

Methods	4‐week cross‐over trial of dimethylglycine versus placebo
Participants	Inclusion and exclusion criteria: unclear, details not provided Location/setting: China Sample size: 106 (unclear how many in each group) Number of dropouts/withdrawals: 61 participants in total "(At the end of the first 4 weeks 22 cases (21%) were lost. At the end of 10 weeks 61 cases (58%) were lost which was inadequate for analysis. Therefore we decided to use the data from the first 4 weeks for our main analysis."
Interventions	Phase one Intervention (dimethylglycine): participants received between 6.94 mg and 10.41 mg/kg body weight for 4 weeks. This was followed by a 2‐week wash‐out period before commencing placebo. Comparator: equivalent placebo for 4 weeks. This was followed by a 2‐week wash‐out period before commencing dimethylglycine.
Outcomes	Primary outcomes: AEs irritability (although unclear which scale was used) Secondary outcomes: it appears that none were reportd although it is difficult to know Timing of outcome assessments: details not provided
Notes	Contact person: details not provided Contact details: details not provided