TABLE 1.
Structural features of the different parenteral formulations of amphotericin B and nystatina
| Formulation | Composition | Molar ratio | Structure | Particle size |
|---|---|---|---|---|
| Fungizone | Sodium deoxycholate-amphotericin B | 4:5 | Colloidal dispersion | NA |
| AmBisome | HSPC-cholesterol-DSPG-amphotericin B | 10:5:4:2 | Unilamellar liposome | 80 nm |
| Amphocil (ABCD) | Sodium cholesteryl sulfate-amphotericin B | 1:1 | Lipid disc | 120 nm |
| Abelcet (ABLC) | DMPC-DMPG-amphotericin B | 7:3:10 | Lipid ribbon | 2–5 μm |
| Nyotran | DMPC-DMPG-nystatin | 7:3:1 | Multilamellar liposome | 0.1–3 μm |
a
HSPC, hydrogenated soy phosphatidylcholine; DSPG, distearoylphosphatidylglycerol; NA, not applicable.