TABLE 2.
In vitro susceptibilities of 200 isolates to four amphotericin B and two nystatin formulations
| Species (no. of isolates) | Antifungal agent | MIC (μg/ml)
|
MLC (μg/ml)
|
||||
|---|---|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | Range | MLC50 | MLC90 | ||
| A. flavus (10) | ABLC | 2–>8 | 8 | >8 | 2–>8 | 8 | >8 |
| Amphotericin B deoxycholate | 0.5–2 | 1 | 1 | 0.5–2 | 1 | 1 | |
| ABCD | 8–>8 | >8 | >8 | 8–>8 | >8 | >8 | |
| Liposomal amphotericin B | >8 | >8 | >8 | >8 | >8 | >8 | |
| Liposomal nystatin | 2–4 | 4 | 4 | 4–8 | 4 | 8 | |
| Nystatin | 4–8 | 8 | 8 | 4–>8 | 8 | 8 | |
| A. fumigatus (30) | ABLC | 0.12–0.25 | 0.25 | 0.5 | 0.12–4 | 0.5 | 2 |
| Amphotericin B deoxycholate | 0.5–2 | 1 | 1 | 0.5–8 | 1 | 4 | |
| ABCD | 4–>8 | 8 | 8 | 4–>8 | 8 | >8 | |
| Liposomal amphotericin B | 8–>8 | >8 | >8 | >8 | >8 | >8 | |
| Liposomal nystatin | 1–4 | 2 | 4 | 2–>8 | 4 | 8 | |
| Nystatin | 2–>8 | 8 | 8 | 4–>8 | 8 | >8 | |
| C. albicans (40) | ABLC | 0.06–0.25 | 0.12 | 0.12 | 0.12–0.5 | 0.25 | 0.5 |
| Amphotericin B deoxycholate | 0.25–0.5 | 0.25 | 0.25 | 0.25–1 | 0.5 | 0.5 | |
| ABCD | 1–2 | 1 | 1 | 1–8 | 2 | 4 | |
| Liposomal amphotericin B | 2–8 | 4 | 4 | 8–>8 | 8 | >8 | |
| Liposomal nystatin | 1–2 | 1 | 1 | 1–2 | 1 | 2 | |
| Nystatin | 1–2 | 2 | 2 | 1–2 | 2 | 2 | |
| C. glabrata (20) | ABLC | 0.12–0.5 | 0.25 | 0.25 | 0.25–2 | 0.5 | 2 |
| Amphotericin B deoxycholate | 0.25–0.5 | 0.25 | 0.5 | 0.25–0.5 | 0.5 | 0.5 | |
| ABCD | 1–4 | 2 | 2 | 1–4 | 2 | 4 | |
| Liposomal amphotericin B | 4–>8 | 8 | >8 | 8–>8 | >8 | >8 | |
| Liposomal nystatin | 1–4 | 2 | 2 | 2–8 | 2 | 4 | |
| Nystatin | 2–8 | 2 | 4 | 2–8 | 4 | 4 | |
| C. kefyr (10) | ABLC | 0.12–1 | 0.25 | 1 | 0.25–1 | 0.5 | 1 |
| Amphotericin B deoxycholate | 1 | 1 | 1 | 1–2 | 1 | 2 | |
| ABCD | 4–8 | 8 | 8 | 8–>8 | 8 | >8 | |
| Liposomal amphotericin B | >8 | >8 | >8 | >8 | >8 | >8 | |
| Liposomal nystatin | 1–4 | 1 | 4 | 1–4 | 1 | 4 | |
| Nystatin | 2–8 | 4 | 8 | 4–>8 | 4 | >8 | |
| C. krusei (20) | ABLC | 0.06–2 | 0.5 | 1 | 0.25–>8 | 4 | >8 |
| Amphotericin B deoxycholate | 0.12–1 | 0.5 | 1 | 0.25–2 | 0.5 | 1 | |
| ABCD | 2–>8 | 8 | >8 | 4–>8 | >8 | >8 | |
| Liposomal amphotericin B | >8 | >8 | >8 | >8 | >8 | >8 | |
| Liposomal nystatin | 1–4 | 2 | 2 | 2–4 | 4 | 4 | |
| Nystatin | 2–8 | 4 | 8 | 4–>8 | 8 | >8 | |
| C. lusitaniae (10) | ABLC | 0.06–0.25 | 0.12 | 0.25 | 0.12–2 | 0.25 | 1 |
| Amphotericin B deoxycholate | 0.5–2 | 0.5 | 1 | 0.5–2 | 1 | 2 | |
| ABCD | 4–8 | 4 | 8 | 4–>8 | 8 | >8 | |
| Liposomal amphotericin B | 4–>8 | 8 | >8 | 8–>8 | >8 | >8 | |
| Liposomal nystatin | 1–2 | 1 | 2 | 1–4 | 2 | 4 | |
| Nystatin | 2–8 | 4 | 8 | 4–>8 | 4 | >8 | |
| C. parapsilosis (20) | ABLC | 0.06–0.25 | 0.12 | 0.25 | 0.5–4 | 1 | 2 |
| Amphotericin B deoxycholate | 0.25–0.5 | 0.25 | 0.5 | 0.5–2 | 0.5 | 1 | |
| ABCD | 1–2 | 2 | 2 | 2–>8 | 4 | 8 | |
| Liposomal amphotericin B | 2–8 | 8 | 8 | 8–>8 | >8 | >8 | |
| Liposomal nystatin | 1–2 | 1 | 2 | 2–>8 | 4 | 8 | |
| Nystatin | 2–4 | 2 | 4 | 4–8 | 4 | 8 | |
| C. tropicalis (20) | ABLC | 0.12–1 | 0.25 | 1 | 0.25–2 | 1 | 1 |
| Amphotericin B deoxycholate | 0.25–0.5 | 0.5 | 0.5 | 0.25–8 | 0.5 | 0.5 | |
| ABCD | 2–8 | 4 | 8 | 4–8 | 8 | 8 | |
| Liposomal amphotericin B | >8 | >8 | >8 | >8 | >8 | >8 | |
| Liposomal nystatin | 1–4 | 2 | 4 | 2–8 | 2 | 4 | |
| Nystatin | 2–4 | 4 | 4 | 2–>8 | 4 | 8 | |
| C. neoformans (20) | ABLC | 0.03–0.25 | 0.06 | 0.12 | 0.06–0.5 | 0.12 | 0.25 |
| Amphotericin B deoxycholate | 0.12–0.5 | 0.25 | 0.5 | 0.25–2 | 0.5 | 0.5 | |
| ABCD | 1–4 | 2 | 4 | 2–>8 | 4 | 8 | |
| Liposomal amphotericin B | 4–>8 | 8 | >8 | >8 | >8 | >8 | |
| Liposomal nystatin | 1–4 | 1 | 4 | 1–8 | 2 | 4 | |
| Nystatin | 1–8 | 1 | 8 | 2–>8 | 2 | >8 | |