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. 2023 Oct 9;21:702. doi: 10.1186/s12967-023-04519-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — MAGEA expression level strongly associates with therapeutic response and patient prognosis in multiple cancers. Analysis of MAGEA expression in human gastric cancer (n = 152–875 patient samples, KM plotter database), non-small cell lung carcinoma (NSCLC) (n = 1926 patient samples, KM plotter database), breast cancer (n = 2976 patient samples, KM plotter database), pancreatic ductal adenocarcinoma (PDAC) (n = 177 patients, KM plotter database, n = 22–46 patients, our cohort), and on the basis of KM plotter database and our collected patient cohort. A–F Kaplan–Meier survival study of the MAGEA expression in human GC, NSCLC, BC and PDAC patients. Representative images of MAGEA IHC staining from tumor sections are given here. G–I Correlation studies between MAGEA expression and tumor size/enhanced cancer progression/lymph node metastases in PDAC patients. Means ± S.E.M are given. J–N The chemotherapy treated cancer patients with high MAGEA expression were associated with increased incidence of relapse or/and worse overall survival in gastric cancer (n = 152 patients, KM plotter database), breast cancer (n = 1195 patients, KM plotter database), NSCLC (n = 173 patients, KM plotter database) and PDAC patients (n = 22 patients, our cohort) respectively. A–D, F, K–N Log-rank (Mantel-Cox) test. G, I Student’s t test. H One-way ANOVA. J Chi-square test. Scale bar in (E) represents 100 μm