Table 2.
Covariate-adjusted Least Square Means of Volumetric Percent Density by Quartiles of the 14 Lipid Sub-pathways
| Lipid pathway a,b,c | Q1LSM (95% CI) | Q2LSM (95% CI) | Q3LSM (95% CI) | Q4LSM (95% CI) | p-trend | FDR p-trend | Bonferroni p-trend |
|---|---|---|---|---|---|---|---|
| Phospholipids | |||||||
| PC | 8.5 (7.7–9.5) | 8.4 (7.5–9.3) | 7.9 (7.1–8.8) | 8.1 (7.3–9.0) | 0.30 | 0.55 | 1 |
| LPC | 7.6 (6.9–8.5) | 8.4 (7.6–9.3) | 8.4 (7.6–9.3) | 8.5 (7.7–9.5) | 0.07 | 0.18 | 1 |
| PE | 8.7 (7.8–9.6) | 8.0 (7.2–8.9) | 8.3 (7.5–9.3) | 7.9 (7.1–8.8) | 0.15 | 0.35 | 1 |
| LPE | 8.1 (7.3–9.0) | 8.1 (7.3–9.0) | 8.3 (7.5–9.2) | 8.4 (7.6–9.3) | 0.46 | 0.63 | 1 |
| PI | 8.3 (7.5–9.2) | 8.4 (7.6–9.4) | 8.2 (7.4–9.1) | 8.0 (7.2–8.9) | 0.43 | 0.63 | 1 |
| Sphingolipids | |||||||
| CER | 9.0 (8.1–9.9) | 8.4 (7.6–9.3) | 7.6 (6.9–8.5) | 7.8 (7.1–8.7) | 0.008 | 0.04 | 0.33 |
| DCER | 9.2 (8.3–10.2) | 8.2 (7.4–9.1) | 7.9 (7.1–8.7) | 7.5 (6.8–8.4) | 0.0004 | 0.003 | 0.02 |
| HCER | 7.7 (6.9–8.5) | 8.5 (7.6–9.4) | 8.2 (7.4–9.1) | 8.7 (7.8–9.6) | 0.05 | 0.14 | 1 |
| LCER | 7.5 (6.8–8.3) | 8.3 (7.5–9.2) | 8.2 (7.4–9.1) | 9.3 (8.3–10.3) | 0.0002 | 0.002 | 0.009 |
| SM | 8.3 (7.5–9.2) | 8.6 (7.8–9.6) | 8.3 (7.5–9.2) | 7.6 (6.8–8.4) | 0.05 | 0.15 | 1 |
| Neutral complex lipids | |||||||
| CE | 8.4 (7.6–9.3) | 8.7 (7.8–9.6) | 8.2 (7.4–9.1) | 7.5 (6.7–8.3) | 0.01 | 0.04 | 0.42 |
| DAG | 9.0 (8.1–9.9) | 8.5 (7.7–9.5) | 8.1 (7.3–9.0) | 7.3 (6.6–8.1) | 0.0002 | 0.002 | 0.008 |
| TAG | 8.9 (8.0–9.9) | 9.2 (8.3–10.2) | 7.7 (7.0–8.5) | 7.2 (6.5–8.1) | 1.7E-05 | 0.0003 | 0.0007 |
| MAG | 8.6 (7.7–9.5) | 8.1 (7.3–8.9) | 7.9 (7.1–8.7) | 8.4 (7.6–9.4) | 0.63 | 0.71 | 1 |
aModels were adjusted for age (continuous), age at menarche (continuous), body fat % (continuous), race (non-Hispanic white, non-Hispanic black,
other), family history of breast cancer (yes, no), oral contraceptive use (never, less than 1 year, 1–4 years, 5–9 years, more than 10 years),
alcohol consumption (never, less than 1 drink per week, 1–2 drinks per week, 3–5 drinks per week, and 6 + drinks per week), parity/age at first birth (nulliparous, 1–2 children & < 25 years, 1–2 children & 25–29 years, 1–2 children &, ≥ 30 years, ≥ 3 children & < 25 years,
≥ 3 children & ≥ 25 years) and body shape at age 10 (1&2, 3&4, 5, 6–9)
bVolumetric percent density was log10 transformed and coefficients were back-transformed (10^β), and bolded if the Bonferroni p-trend is < 0.05
cQuartile values: PC, Q1 = (1165 μM-1848 μM), Q2 = (> 1848 μM-2097 μM), Q3 = (> 2097 μM-2460 μM), Q4 = (> 2460 μM-4298 μM); LPC, Q1 = (60.1 μM-144 μM),
Q2 = (> 144 μM-169 μM), Q3 = (> 169 μM-199 μM), Q4 = (> 199 μM-312 μM); PE, Q1 = (76.6-167 μM), Q2 = (> 167-195 μM), Q3 = (> 195-231 μM), Q4 = (> 231-471 μM);
LPE, Q1 = (2.34–4.82 μM), Q2 = (> 4.82–5.84 μM), Q3 = (> 5.84–7.08 μM), Q4 = (> 7.08–12.04 μM); PI, Q1 = (2.68,-6.44 μM), Q2 = (> 6.44–7.75 μM),
Q3 = (> 7.75–9.39 μM), Q4 = (> 9.39–18.77 μM); CER, Q1 = (3.04–5.58 μM), Q2 = (> 5.58–6.49 μM), Q3 = (> 6.49–7.43 μM), Q4 = (> 7.43–15.57 μM); DCER, Q1 = (0.879–1.66 μM), Q2 = (> 1.66–1.92 μM), Q3 = (> 1.92–2.25 μM), Q4 = (> 2.25–4.60 μM); HCER, Q1 = (1.78–3.38 μM), Q2 = (> 3.38–4.02 μM), Q3 = (> 4.02–4.67 μM), Q4 = (> 4.67–10.27 μM); LCER, Q1 = (1.47–2.92 μM), Q2 = (> 2.92–3.56 μM), Q3 = (> 3.56–4.29 μM), Q4 = (> 4.29–17.27 μM); SM, Q1 = (354-523 μM), Q2 = (> 523-586 μM), Q3 = (> 586-643 μM), Q4 = (> 643-1118 μM); CE, Q1 = (1066-1832 μM), Q2 = (> 1832-2062 μM), Q3 = (> 2062-2337 μM), Q4 = (> 2337-4335 μM); DAG, Q1 = (5.26–16.1 μM), Q2 = (> 16.1–22.1 μM), Q3 = (> 22.1–32.3 μM), Q4 = (> 32.3–106.8 μM); TAG, Q1 = (276-748 μM), Q2 = (> 748-1018 μM), Q3 = (> 1018-1516 μM), Q4 = (> 1516-6296 μM); MAG, Q1 = (0.23–0.79 μM), Q2 = (> 0.79–1.71 μM), Q3 = (> 1.71–12.89 μM), Q4 = (> 12.89–56.82 μM); Abbreviations: phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), lysophosphatidylethanolamine (LPE),
phosphatidylinositol (PI), ceramide (CER), dihydroceramide (DCER), hexosylceramide (HCER), lactosylceramide (LCER), sphingomyelin (SM),
cholesteryl ester (CE), diacylglycerol (DAG), triacylglycerol (TAG), monoacylglycerol (MAG), quartiles 1–4 (Q1-4), least square mean (LSM),
confidence interval (CI), false discovery rate (FDR)