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. 2023 Oct 9;22:169. doi: 10.1186/s12943-023-01865-0

Table 5.

Nanocarrier drug release kinetics

Nanocarrier Type Drug Type Release Mechanism Release Rate pH Sensitivity Stability References
Liposomes Doxorubicin pH Gradient Sustained Acidic Stable [13]
Polymeric nanoparticles Paclitaxel Diffusion Controlled Neutral Stable [90, 102]
Dendrimers Methotrexate Swelling Pulsatile Basic Unstable [99]
Nanoemulsions Docetaxel Partitioning Pulsatile Acidic Stable [117]
Gold nanoparticles Curcumin Photothermal Triggered Neutral Stable [90, 102]
Iron oxide nanoparticles Doxorubicin Magnetic field Sustained Neutral Stable [121]
Lipid-based Paclitaxel Diffusion Sustained Acidic Stable [57]
Polymer-lipid hybrid Cisplatin Hydrolysis Burst Neutral Unstable [57]
Carbon-based Cisplatin Adsorption Triggered Neutral Unstable [90, 102]
Gold nanorods Doxorubicin Photothermal Pulsatile Neutral Stable [90, 102]
Silica nanoparticles Curcumin pH-Responsive Sustained Neutral Stable [88]
Polymer nanoparticles Paclitaxel Erosion Sustained Neutral Stable [90, 102]
Liposomes Curcumin Gradient Sustained Neutral Stable [13]
Gold nanoparticles Doxorubicin Photothermal Pulsatile Neutral Stable [90, 102]
Polymeric micelles Docetaxel Solubilization Controlled Neutral Stable [91]
Carbon nanotubes Cisplatin Diffusion Sustained Neutral Unstable [90, 102]
Metal–organic frameworks Methotrexate Degradation Sustained Basic Unstable [101]
Polymeric nanoparticles Doxorubicin Degradation Sustained Neutral Stable [90, 102]
Liposomes Methotrexate pH Gradient Controlled Acidic Stable [13]
Dendrimers Paclitaxel Swelling Controlled Neutral Unstable [99]
Nanoemulsions Curcumin Partitioning Sustained Neutral Stable [117]
Liposomes Doxorubicin pH Gradient Sustained Acidic Stable [13]
Polymeric nanoparticles Paclitaxel Diffusion Controlled Neutral Stable [90, 102]
Dendrimers Methotrexate Swelling Pulsatile Basic Unstable [99]
Nanoemulsions Docetaxel Partitioning Pulsatile Acidic Stable [117]
Gold nanoparticles Curcumin Photothermal Triggered Neutral Stable [117]
Iron oxide nanoparticles Doxorubicin Magnetic field Sustained Neutral Stable [121]
Lipid-based Paclitaxel Diffusion Sustained Acidic Stable [57]
Polymer-lipid hybrid Cisplatin Hydrolysis Burst Neutral Unstable [57]
Carbon-based Cisplatin Adsorption Triggered Neutral Unstable [90, 102]
Gold nanorods Doxorubicin Photothermal Pulsatile Neutral Stable [58]
Silica nanoparticles Curcumin pH-Responsive Sustained Neutral Stable [88]