Table 5.

Renal outcomes

Study	Complete renal remission	Partial renal remission
Abatacept
ACCESS 2014 [4]	UPCR < 0.5 based on a 24-h urine collection, Serum creatinine ≤ 1.2 mg/dl or ≤ 125% of baseline Adherence to the prednisone taper to 10 mg/day by week12	UPCR 50% improvement from baseline Serum creatinine ≤ 1.2 mg/dl or ≤ 125% of baseline Adherence to the prednisone taper to 10 mg/day by week12
Furie 2014 [3]	EGFR 90% of screening level if normal at screening visit or eGFR 90% of 6-month, pre-flare value if abnormal at screening, UPCR 0.26 gm/gm (30 mg/mmole) Inactive urinary sediment (RBCs and WBCs per hpf within normal limits, no RBC or WBC casts All complete response criteria had to be met once again, 4 weeks after they were initially achieved	Inactive urinary sediment regardless of the screening value UPCR 50% improvement from screening value eGFR ≥ 90% of screening value if eGFR 60–89  ≥ 50% improvement in eGFR if screening eGFR was between 15–59, or eGFR ≥ 90% of the screening or 6 month pre-flare value
Furie 2018 [5]	Maintenance of GFR UPCR ≤ 0.5 Absence of urinary cellular casts Pednisone ≤ 10 mg/day	None
Belimumab
Furie 2020 [16]	UPCR of < 0.5 eGFR that was no worse than 10% below the preflare value or ≥ 90 No rescue therapy	≥ 50% decrease in the uPCR and either uPCR < 1.0, if the baseline ratio was ≤ 3.0 or < 3.0, if the baseline ratio was > 3.0
Atisha-Fregoso 2021 [17]	UPCR of < 0.5 based on a 24-h urine sample collection eGFR of ≥ 120 or if the value was < 120, then > 80% of the eGFR recorded at the time of study entry Adherence to the prednisone dosing provisions. (prednisone 40 mg/day with taper to 10 mg/day by week 12, and ≤ 10 mg/day through week 96.)	eGFR no more than 10% below the baseline value or within normal range
Ocrelizumab
Mysler 2013 [26]	Serum creatinine ≤ 25% increase from baseline UPCR < 0.5	Serum creatinine ≤ 25% above baseline 50% improvement in UPCR, if baseline ratio > 3.0, then UPCR < 3.0
Obinutuzumab
Furie 2019 [7]	Maintenance of eGFR, UPCR) ≤ 0.5 Absence of urinary cellular casts Prednisone ≤ 10 mg/day	Serum creatinine ≤ 15% above baseline value No urinary red cell casts and either RBCs/HPF ≤ 50% above baseline or < 10 RBCs/HPF 50% improvement in UPCR, with one of following conditions met: If baseline UPCR is ≤ 3.0, then a UPCR of < 1.0 If baseline UPCR > 3.0, then a UPCR of < 3.0
Rituximab
Rovin 2012 [28]	Normal creatinine level if it was abnormal at baseline or a creatinine level of ≤ 115% of baseline if it was normal at baseline Inactive urinary sediment (< 5 RBCs/hpf and absence of RBC casts); and UPCR ratio < 0.5	Creatinine level ≤ 115% of baseline RBCs/hpf ≤ 50% above baseline and no RBC casts At least a 50% decrease in the UPC ratio to < 1.0 (if the baseline UPC ratio was ≤ 3.0) or to ≤ 3.0 (if the baseline UPC ratio was > 3.0)