TABLE 1.
Comparison of measured and pharmacokinetic-model-predicted sparfloxacin concentrations in serum and vitreous humor following systemic administration
| Time (h) | Sparfloxacin level (μg/ml) in:
|
|||
|---|---|---|---|---|
| Serum
|
Vitreous humor
|
|||
| Measured | Predicted | Measured | Predicted | |
| 0.25 | 12.42 ± 3.86 | 12.355 | 1.638 ± 0.844 | 1.6642 |
| 0.5 | 7.89 ± 1.86 | 7.9837 | 2.702 ± 0.765 | 2.4495 |
| 1.0 | 4.708 ± 0.72 | 4.6642 | 2.836 ± 0.484 | 2.9741 |
| 2.0 | 3.429 ± 0.54 | 3.0106 | 2.706 ± 0.496 | 2.7177 |
| 3.0 | 2.059 ± 0.27 | 2.2635 | 2.267 ± 0.462 | 2.2234 |
| 4.0 | 1.589 ± 0.12 | 1.7190 | 1.909 ± 0.424 | 1.7928 |
| 6.0 | 0.961 ± 0.045 | 0.9928 | 1.056 ± 0.224 | 1.1605 |
| 8.0 | 0.611 ± 0.085 | 0.5734 | 0.781 ± 0.235 | 0.7509 |