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Comparison of the effects of probenecid on the half-lives for elimination from the vitreous humor of quinoline antimicrobials
| Regimen | t1/2β ± SD (h) | Median (h) | P value |
|---|---|---|---|
| Ciprofloxacin | 4.41 ± 1.69 | 4.064 | |
| Ciprofloxacin + probenecid | 9.66 ± 0.81 | 9.53 | 0.014 |
| Fleroxacin | 335 ± 0.26 | 3.35 | |
| Fleroxacin + probenecid | 5.52 ± 0.83 | 5.52 | 0.002 |
| Ofloxacin | 3.04 ± 0.70 | 3.30 | |
| Ofloxacin + probenecid | 4.15 ± 3.93 | 0.15 | |
| Sparfloxacin | 2.78 ± 0.63 | 2.59 | |
| Sparfloxacin + probenecid | 4.60 ± 1.34 | 4.37 | 0.05 |
