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. 2023 Oct 3;10(10):ENEURO.0089-23.2023. doi: 10.1523/ENEURO.0089-23.2023

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Copyright © 2023 Hernández-Vivanco et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Kainic acid-induced increases in synaptic activity prevent the induction of iLTP in GCs. A, Schematic of experimental procedure. B, Representative example of c-Fos (green) expression in the DGs of vehicle- and KA-injected mice. Boxed regions in top panels are shown in bottom panels. Scale bars: top, 500 μm; bottom, 50 μm. C, Representative traces of eIPSCs before (Bsl) and after FSK bath application recorded from GCs in vehicle- and KA-treated mice. Calibration: 25 ms, 50 pA. D, Time course of FSK effects on normalized eIPSC amplitude in GCs from vehicle- and KA-treated mice. Vehicle-injected mice, n = 8 GCs; KA-injected mice, n = 11 GCs. E, Proportion of recorded GCs showing a significant increase of eIPSC amplitude after FSK application in the vehicle- and KA-treated mice. Two-sided Fisher’s exact test, p = 0.001; vehicle-treated mice, n = 8 GCs; KA-injected mice, n = 11 GCs. F, Population data of FSK effects on normalized eIPSC amplitude before (Bsl) and after FSK application in GCs from vehicle- and KA-injected mice. Two-way ANOVA; Vehicle versus KA: F_(1,17) = 15.85, p = 0.001; Bonferroni’s multiple-comparisons test; Vehicle Bsl versus FSK, p = 0.004; KA Bsl versus FSK, p = 0.19; vehicle-treated mice, n = 8 GCs; KA-injected mice, n = 11 GCs. G, Population data for eIPSC PPR calculated before (Bsl) and after FSK application in GCs from vehicle- and KA-injected mice. Two-way ANOVA; Vehicle versus KA: F_(1,17) = 2.43, p = 0.14; Bonferroni’s multiple-comparisons test; vehicle Bsl versus FSK, p = 0.02; KA Bsl versus FSK, p = 0.99; Bsl Vehicle versus KA, p = 0.02; vehicle-treated mice, n = 8; KA-injected mice, n = 11 GCs. *p < 0.05; n.s., nonsignificant. Dots and vertical bars in D and horizontal and vertical bars in F represent the mean ± SEM. Dots in F and G represent individual measurements.