Table 2.
Comparisons of baseline characteristics between different risk subgroups
| Characteristics | Low risk | Int risk | High risk | P int/low | P high/low | P high/int |
|---|---|---|---|---|---|---|
| n = 89 | n = 18 | n = 13 | ||||
| Age of diagnosis, year, median (IQR) | 59 (49–64) | 56 (49–67) | 65 (61–77) | 0.825 | 0.062 | 0.147 |
| Male sex, n (%) | 44 (49.4) | 10 (55.6) | 8 (61.5) | 0.636 | 0.415 | 1.000 |
| Symptomatic, n (%) | 62 (69.7) | 17 (94.4) | 13 (100) | 0.059 | 0.048 | 1.000 |
| Fatigue, n (%) | 45 (50.6) | 11 (61.1) | 13 (100) | 0.414 | 0.001 | 0.025 |
| Recurrent infections, n (%) | 12 (13.5) | 7 (38.9) | 3 (23.1) | 0.025 | 0.622 | 0.452 |
| Autoimmune phenomenon, n (%) | 28 (31.5) | 10 (55.6) | 10 (76.9) | 0.051 | 0.004 | 0.275 |
| B symptoms, n (%) | 11 (12.4) | 8 (44.4) | 5 (38.5) | 0.004 | 0.045 | 1.000 |
| Hepatomegaly, n (%) | 2 (2.2) | 1 (5.6) | 1 (7.7) | 1.000 | 0.836 | 1.000 |
| Splenomegaly, n (%) | 14 (15.7) | 7 (38.9) | 3 (23.1) | 0.054 | 0.791 | 0.452 |
| Lymphadenopathy, n (%) | 10 (11.2) | 7 (38.9) | 1 (7.7) | 0.010 | 1.000 | 0.095 |
| ECOG PS >2, n (%) | 0 (0) | 0 (0) | 13 (100) | – | <0.001 | <0.001 |
| LGL, × 109/L, median (IQR) | 2.97 (1.16, 4.54) | 1.81 (1.01, 4.09) | 2.91 (0.73, 4.13) | 0.363 | 0.416 | 0.837 |
| ALC, × 109/L, median (IQR) | 3.9 (2.25, 6.98) | 2.75 (1.89, 5.85) | 2.1 (1.07, 5.18) | 0.224 | 0.138 | 0.465 |
| ANC, × 109/L, median (IQR) | 1.38 (0.83, 2.26) | 1.5 (0.52, 2.55) | 1.41 (1.05, 2.64) | 0.774 | 0.446 | 0.496 |
| Hemoglobin, g/L, median (IQR) | 85 (64, 123) | 95.5 (68.25, 111.75) | 75 (61, 88) | 0.864 | 0.049 | 0.033 |
| Platelets, × 109/L, median (IQR) | 199 (162, 236) | 68 (34.25, 76.75) | 168 (55, 282) | <0.001 | 0.388 | 0.003 |
| LDH, U/L, median (IQR) | 195.5 (169, 231.25) | 239.5 (199.25, 297.75) | 236 (215.75, 302.5) | 0.023 | 0.005 | 0.882 |
| Positive STAT3 mutation, n (%) | 11 (17.2) | 3 (30) | 0 (0) | 0.598 | 0.580 | 0.250 |
| Pure red-cell anemia, n (%) | 21 (23.6) | 2 (11.1) | 7 (53.8) | 0.389 | 0.051 | 0.017 |
| Rheumatoid arthritis, n (%) | 4 (4.5) | 1 (5.6) | 1 (7.7) | 1.000 | 1.000 | 1.000 |
| aCCI score > 2, n (%) | 18 (20.2) | 4 (22.2) | 10 (76.9) | 1.000 | <0.001 | 0.004 |
Missing data: STAT3 mutations (n = 40).
Int: intermediate; IQR: interquartile range; ECOG PS: Eastern Cooperative Oncology Group performance status; LGL: large granular lymphocyte; ALC: absolute lymphocyte count; ANC: absolute neutrophil count; LDH: lactate dehydrogenase; aCCI: age-adjusted Charlson Comorbidity Index.
Statistically significant p-values are written in bold.