Table 3.
Associations Between the Number of (A) Viral (N=851) and (B) Respiratory (N = 853) Infections Experienced by Each Child and Wheeze Trajectory
| (A) | ||||||
|---|---|---|---|---|---|---|
| Viral infections | Early-onset |
Late-onset |
Persistent |
|||
| AOR (95% CI)a | P | AOR (95% CI)a | P | AOR (95% CI)a | P | |
| Number of viral infections from 0 to 2 y | 4.97 (3.43-7.21) | <.001 | 1.75 (1.24-2.45) | .001 | 2.39 (1.60-3.58) | <.001 |
| Number of viral infections from 2 to 4 y | 7.37 (4.12-13.19) | <.001 | 9.22 (5.42-15.68) | <.001 | 10.33 (5.23-20.40) | <.001 |
| Number of viral infections from 4 to 6 y | 1.28 (0.31-5.18) | .73 | 8.01 (4.23-15.16) | <.001 | 12.80 (5.90-27.74) | <.001 |
| Number of viral infections from 6 to 8 y | 1.52 (0.27-8.73) | .64 | 3.66 (1.55-8.63) | .003 | 10.60 (4.02-27.94) | <.001 |
| (B) | ||||||
| Respiratory infections | Early-onset |
Late-onset |
Persistent |
|||
| AOR (95% CI)a | P | AOR (95% CI)a | P | AOR (95% CI)a | P | |
| Number of respiratory infections from 0 to 2 y | 4.96 (3.40-7.22) | <.001 | 1.78 (1.28-2.47) | .001 | 2.46 (1.65-3.69) | <.001 |
| Number of respiratory infections from 2 to 4 y | 5.73 (3.26-10.08) | <.001 | 6.95 (4.09-11.81) | <.001 | 7.94 (4.22-14.94) | <.001 |
| Number of respiratory infections from 4 to 6 y | 1.03 (0.27-3.89) | .97 | 5.84 (3.21-10.60) | <.001 | 9.74 (4.69-20.24) | <.001 |
| Number of respiratory infections from 6 to 8 y | 1.15 (0.24-5.59) | .87 | 2.56 (1.21-5.43) | .01 | 6.55 (2.84-15.09) | <.001 |
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval.
a
Reference: No or low wheeze trajectory. Sex, ethnicity, maternal education level, and family history of allergy were adjusted with cluster-robust standard errors.