eTable 5.
Participants With Allergic Comorbidities in Each Wheeze Trajectory
| Allergic comorbidities | Total (n = 974) | No or low wheeze (n = 812) | Early-onset transient (n = 44) | P | Late-onset transient (n = 79) | P | Persistent (n = 39) | P |
|---|---|---|---|---|---|---|---|---|
| Allergic sensitization by 1.5 y | 115 (13.9) | 84 (12.1) | 2 (5.3) | .30 | 18 (27.7) | <.001 | 11 (32.4) | .002 |
| Allergic sensitization by 3 y | 231 (29.6) | 169 (26.2) | 13 (34.2) | .28 | 31 (47.0) | <.001 | 18 (58.1) | <.001 |
| Allergic sensitization by 5 y | 351 (47.8) | 270 (44.9) | 18 (48.7) | .66 | 37 (56.9) | .07 | 26 (83.9) | <.001 |
| Allergic sensitization by 8 y | 515 (70.0) | 411 (68.3) | 27 (75.0) | .40 | 45 (72.6) | .49 | 32 (88.9) | .009 |
| Eczema by 1.5 y | 166 (21.5) | 112 (17.6) | 12 (32.4) | .02 | 24 (36.4) | <.001 | 18 (52.9) | <.001 |
| Eczema by 3 y | 209 (28.4) | 146 (24.3) | 13 (35.1) | .14 | 31 (47.0) | <.001 | 19 (59.4) | <.001 |
| Eczema by 5 y | 226 (33.5) | 158 (28.8) | 15 (42.9) | .08 | 32 (51.6) | <.001 | 21 (70.0) | <.001 |
| Eczema by 8 y | 266 (33.8) | 192 (29.6) | 17 (46.0) | .04 | 36 (53.7) | <.001 | 21 (61.8) | <.001 |
| Rhinitis by 1.5 y | 397 (49.7) | 300 (45.9) | 33 (84.6) | <.001 | 40 (58.8) | .04 | 24 (63.2) | .04 |
| Rhinitis by 3 y | 489 (61.1) | 380 (57.8) | 34 (85.0) | .001 | 48 (70.6) | .04 | 27 (77.1) | .02 |
| Rhinitis by 5 y | 509 (65.9) | 399 (62.9) | 34 (85.0) | .005 | 49 (75.4) | .046 | 27 (79.4) | .051 |
| Rhinitis by 8 y | 548 (64.1) | 432 (61.3) | 35 (81.4) | .008 | 54 (77.1) | .009 | 27 (73.0) | .15 |
| Atopic eczema by 1.5 y | 40 (5.7) | 24 (4.1) | 1 (2.9) | >.99 | 6 (10.5) | .03 | 9 (30.0) | <.001 |
| Atopic eczema by 3 y | 70 (10.4) | 40 (7.3) | 6 (16.7) | .04 | 11 (18.6) | .003 | 13 (46.4) | <.001 |
| Atopic eczema by 5 y | 93 (15.8) | 56 (11.7) | 8 (23.5) | .04 | 15 (28.3) | .001 | 14 (58.3) | <.001 |
| Atopic eczema by 8 y | 143 (20.0) | 101 (17.0) | 7 (21.9) | .48 | 17 (29.8) | .02 | 18 (56.3) | <.001 |
| Atopic rhinitis by 1.5 y | 61 (8.6) | 42 (7.1) | 2 (5.9) | >.99 | 9 (16.1) | .02 | 8 (23.5) | .001 |
| Atopic rhinitis by 3 y | 108 (15.2) | 71 (12.1) | 8 (21.1) | .11 | 18 (31.0) | <.001 | 11 (36.7) | <.001 |
| Atopic rhinitis by 5 y | 144 (22.2) | 100 (18.8) | 13 (37.1) | .008 | 18 (34.0) | .008 | 13 (48.2) | <.001 |
| Atopic rhinitis by 8 y | 236 (32.8) | 183 (30.6) | 15 (45.5) | .07 | 21 (38.2) | .25 | 17 (51.5) | .01 |
| Eczema with steroids use by 1.5 y | 92 (12.7) | 61 (10.1) | 7 (20.0) | .07 | 13 (22.0) | .006 | 11 (36.7) | <.001 |
| Eczema with steroids use by 3 y | 112 (16.7) | 76 (13.7) | 7 (20.6) | .27 | 16 (29.1) | .002 | 13 (46.4) | <.001 |
| Eczema with steroids use by 5 y | 120 (20.2) | 82 (16.7) | 7 (23.3) | .35 | 18 (36.0) | .001 | 13 (52.0) | <.001 |
| Eczema with steroids use by 8 y | 161 (21.4) | 114 (18.4) | 10 (27.8) | .16 | 22 (34.4) | .002 | 15 (45.5) | <.001 |
| Sensitization to food by 1.5 y | 38 (4.6) | 27 (3.9) | 1 (2.6) | >.99 | 4 (6.2) | .33 | 6 (17.7) | .003 |
| Sensitization to food by 3 y | 45 (5.9) | 33 (5.2) | 2 (5.4) | >.99 | 4 (6.5) | .56 | 6 (20.0) | .006 |
| Sensitization to food by 5 y | 74 (11.1) | 55 (10.0) | 4 (11.4) | .77 | 8 (14.8) | .27 | 7 (28.0) | .01 |
| Sensitization to food by 8 y | 117 (19.6) | 80 (16.2) | 9 (28.1) | .08 | 15 (31.9) | .007 | 13 (54.2) | <.001 |
| Sensitization to dust mite by 1.5 y | 95 (11.4) | 70 (10.1) | 1 (2.6) | .16 | 16 (24.2) | .001 | 8 (23.5) | .02 |
| Sensitization to dust mite by 3 y | 212 (27.1) | 155 (23.9) | 12 (31.6) | .29 | 29 (43.9) | <.001 | 16 (53.3) | <.001 |
| Sensitization to dust mite by 5 y | 334 (45.6) | 255 (42.5) | 18 (48.7) | .46 | 36 (55.4) | .047 | 25 (83.3) | <.001 |
| Sensitization to dust mite by 8 y | 502 (68.8) | 400 (66.9) | 27 (75.0) | .31 | 43 (71.7) | .45 | 32 (88.9) | .006 |
NOTE. Sample used to study the associations was smaller because of missing values. Benjamini-Hochberg procedure with a 5% false discovery rate was applied.