eTable 7.
Associations Between Wheeze Trajectory and Food and Dust Mite Sensitization
| Allergic sensitisation | n | Early-onset |
Late-onset |
Persistent |
|||
|---|---|---|---|---|---|---|---|
| ARR (95% CI)a | P | ARR (95% CI)a | P | ARR (95% CI)a | P | ||
| Sensitization to food by 1.5 y | 760 | 0.64 (0.09-4.39) | .65 | 1.68 (0.62-4.56) | .31 | 4.20 (1.72-10.25) | .002 |
| Sensitization to food by 3 y | 693 | 0.53 (0.08-3.65) | .52 | 1.43 (0.53-3.87) | .48 | 4.02 (1.65-9.78) | .002 |
| Sensitization to food by 5 y | 605 | 0.95 (0.32-2.80) | .93 | 1.69 (0.85-3.35) | .14 | 2.85 (1.37-5.94) | .005 |
| Sensitization to food by 8 y | 545 | 1.70 (0.93-3.08) | .08 | 2.15 (1.35-3.42) | .001 | 3.20 (2.04-5.02) | <.001 |
| Sensitization to dust mite by 1.5 y | 762 | — | — | 2.39 (1.51-3.79) | <.001 | 2.30 (1.20-4.42) | .01 |
| Sensitization to dust mite by 3 y | 707 | 1.33 (0.77-2.28) | .30 | 1.97 (1.45-2.68) | <.001 | 2.07 (1.36-3.15) | .001 |
| Sensitization to dust mite by 5 y | 659 | 1.23 (0.86-1.74) | .26 | 1.37 (1.09-1.71) | .007 | 1.91 (1.52-2.40) | <.001 |
| Sensitization to dust mite by 8 y | 655 | 1.18 (0.98-1.42) | .09 | 1.11 (0.95-1.30) | .20 | 1.27 (1.09-1.47) | .002 |
Abbreviations: ARR, adjusted relative risk; CI, confidence interval.
NOTE. Poisson regression with robust error variance was implemented with adjustment for sex, ethnicity, maternal education level, and family history of allergy for each allergic comorbidity.
a
Reference: No or low wheeze trajectory.