Table 7. Enrichment analysis of top predicted phosphorylation substrates of HIPK3 kinase.
Category | GO ID | Term description | Fold enrichment | False discovery rate |
---|---|---|---|---|
Biological Process | GO:0030518 | Intracellular steroid hormone receptor signaling pathway | 11.946 | 1.73E−02 |
GO:1903055 | Positive regulation of extracellular matrix organization | 11.946 | 8.43E−02 | |
GO:1901522 | Positive regulation of transcription from RNA polymerase II promoter involved in the cellular response to chemical stimulus | 9.955 | 3.58E−02 | |
GO:0040029 | Regulation of gene expression, epigenetic | 8.959 | 8.80E−07 | |
GO:0035067 | Negative regulation of histone acetylation | 8.533 | 6.30E−02 | |
GO:0001836 | Release of cytochrome c from mitochondria | 7.964 | 1.72E−03 | |
Molecular Function | GO:0051434 | BH3 domain binding | 12.008 | 2.03E−02 |
GO:0005496 | Steroid binding | 9.607 | 4.25E−02 | |
GO:0097199 | Cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 8.006 | 7.50E−02 | |
GO:0070878 | Primary miRNA binding | 7.505 | 2.26E−02 | |
GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | 7.505 | 2.26E−02 | |
Cellular Component | GO:0035976 | Transcription factor AP-1 complex | 12.046 | 4.46E−02 |
GO:0071141 | SMAD protein complex | 9.637 | 8.63E−02 | |
GO:0071159 | NF-kappaB complex | 9.637 | 8.63E−02 | |
GO:0017053 | Transcriptional repressor complex | 5.815 | 5.34E−06 | |
GO:0005667 | Transcription factor complex | 5.163 | 3.69E−17 |