Table 5.
Summary of aquatic and non-aquatic toxicity results for 11 selected derivatives of genistein.
| S/N | AMES-T* | M.TD* (human) mg/kg/day | ORAT (LD50) (mol/kg) | ORCT (mg/kg/day) | HT | SS | T.P Tox (log μg/L) |
|---|---|---|---|---|---|---|---|
| 01 | No | 0.728 | 1.907 | 1.682 | No | No | 0.524 |
| 02 | No | 0.779 | 2.374 | 1.424 | No | No | 0.336 |
| 03 | Yes | 0.438 | 2.482 | 16.892 | No | No | 0.285 |
| 04 | No | 0.578 | 2.542 | 1.877 | No | No | 0.355 |
| 05 | Yes | 0.472 | 2.597 | 1.991 | No | No | 0.376 |
| 06 | No | 0.646 | 2.529 | 1.577 | No | No | 0.419 |
| 07 | No | 0.638 | 2.503 | 1.271 | No | No | 0.511 |
| 08 | Yes | 0.568 | 2.678 | 0.687 | Yes | No | 0.291 |
| 09 | Yes | 0.438 | 2.482 | 50.324 | No | No | 0.285 |
| 10 | Yes | 0.702 | 2.362 | 1.766 | No | No | 0.334 |
| 11 | No | 1.068 | 2.276 | 2.057 | Yes | No | 0.303 |
*AMES toxicity, AMES-T; Max. tolerated dose, M.TD; Oral rat acute toxicity, ORAT; Oral rat chronic toxicity, ORCT, Hepatotoxicity, HT, Skin sensitization, SS, T. pyriformis toxicity, T.P Tox.