Skip to main content
. Author manuscript; available in PMC: 2024 Sep 29.
Published in final edited form as: Circ Res. 2023 Sep 8;133(8):658–673. doi: 10.1161/CIRCRESAHA.123.322567

Figure 7. Cardiac perinexal width inversely correlates with CV.

Figure 7.

A. Representative TEM images of ventricular perinexi (shaded yellow) suggest osmotic agents differentially modulate perinexal width (WP). B. Summary data reveal that relative to Time Control (N=9 hearts, n=140 images), Mannitol significantly increases (N=10 hearts, n=170 images), Albumin significantly decreases (N=12 hearts, n=135 images), Dextran 70k Da does not change (N=5 hearts, n=74 images), and Dextran 2MDa significantly decreases (N=5 hearts, n=75 images) WP. Dashed line represents mean WP for time control. *p<0.05, as evaluated with a generalized linear mixed effects model specifying a gamma distribution and identity link between samples collected from the same heart.