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. 2023 Sep 22;8(18):e166713. doi: 10.1172/jci.insight.166713

Figure 6. Exogenous cBIN1 rescues diastolic heart failure in diabetic mice.

Figure 6

(A) Representative images of longitudinal axis view of left ventricles at end diastolic (top) and systolic (bottom) phases in posttreatment mice (17 weeks of age). Quantification of end-diastolic volume (EDV), cardiac output (CO), and ejection fraction (EF) from each group are included in the bar graphs below (n = 12–17). (B) Representative images of mitral valve inflow pulsed wave Doppler (top) and septal mitral valve annulus tissue Doppler (bottom) in posttreatment mice. Quantification of E/A, E/e’, and isovolumic relaxation time (IVRT) from each group are included in the bar graphs below (n = 11–17). (C and D) The ratio of heart weight (C) and lung weight (D) over tibial length after treatment (n = 13–17). All data are presented as mean ± SEM. One-way ANOVA followed by Bonferroni’s test or Kruskal-Wallis test followed by Dunn’s test was used for comparison between selected pairs. *, **, *** indicates P < 0.05, 0.01, 0.001, respectively, for comparison versus db/m + GFP; †, ††, ††† indicates P < 0.05, 0.01, 0.001, respectively, for comparison between db/db + GFP and db/db + cBIN1.

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