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editorial
. 2023 Oct 6;69(8):e2023D698. doi: 10.1590/1806-9282.2023D698

Table 5. Question: knee infiltration with hyaluronic acid versus steroids - GRADE.

Certainty assessment Patients number Effect Certainty Importance
Studies number Study design Bias risk Inconsistency Indirect evidence Imprecision Other considerations Hyaluronic acid Steroids Relative (95%CI) Absolute (95%CI)
WOMAC score evaluation - Pain
4 Randomized clinical trials Not serious Not serious Not serious Not serious None 255 238 -

  • MD 1.95 higher

  • (0.28 lower to 4.19 higher)

  • ⨁⨁⨁⨁

  • High
VAS score evaluation - Pain
7 Randomized clinical trials Not serious Seriousa Not serious Seriousb None 406 390 -

  • MD 2.05 higher

  • (5 lower to 9.11 higher)

  • ⨁⨁ ◯◯

  • Low
WOMAC overall
2 Randomized clinical trials Not serious Serious a Not serious Not serious None 150 150 -

  • MD 1.06 lower

  • (13.16 lower to 11.03 higher)

  • ⨁⨁⨁ ◯

  • Moderate
Adverse events
4 Randomized clinical trials Not serious Seriousa Not serious Not serious None 244/494 (49.4%) 174/485 (35.9%)

  • 130 less by 1,000

  • (200 less to 60 less)

  • ⨁⨁⨁ ◯

  • Moderate