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Structures and activities of reexamined sulfones
| Compound no. | Compound | Substituent at position:
|
IC50 (μM)a | |||
|---|---|---|---|---|---|---|
| R1 | R2 | R3 | R4 | |||
| 1 | Diformyldapsone | -NHCOH | -NHCOH | 621.8b | ||
| 2 | Difluorodinitrophenylsulfone | -F | -F | -NO2 | -NO2 | 946.4b |
Inhibition was tested at concentrations of 100 and 500 μM, and the resulting data were pooled with earlier inhibition data to generate IC50s as reported previously (7).
The calculated IC50 is outside of the experimental range.
