Fig. 21.

MRI/PAI-guided ferroptosis cancer nanomedicine accelerated by PTT. (a) A schematic diagram of the therapeutic mechanism of FCSP@DOX. (b) A TEM image and elemental mapping of the FCSP MOF. (c) T₂-weighted MR images and the T₂ relaxivity rate according to the concentration of FCSP@DOX. (d) PAI results and intensity according to the concentration of FCSP@DOX. (e) MRI results of 4T1 tumor-bearing mice after injection of FCSP@DOX. (f) PAI results of 4T1 tumor-bearing mice after injection of FCSP@DOX into the tumor sites (n = 3). (g) Relative tumor volume changes after various treatment regimens (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission [123]. Copyright 2021, Elsevier B.V.