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Gene-interference ferroptosis therapy (GIFT). (a) A schematic diagram of CRISPR/cas13a- and miRNA-based GIFT. (b) Stability of the DMSA-coated Fe3O4 nanoparticles over 90 days. (c–d) The in vivo antitumor effect of GIFT in (c) WEHI-3-xenografted mice and (d) CT-26-xenografted mice. Data are presented as the mean ± standard deviation (n = 10 mice). Reproduced with permission [151]. Copyright 2021, Springer Nature.
