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. 2023 Sep 28;23:100813. doi: 10.1016/j.mtbio.2023.100813

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Scheme 2 — Schematic illustration (Created with BioRender.com). Fabrication of HMPs and HMPs@Exos by microfluidics. Following intra-articular injection in a murine DMM model, the HMPs-Exos progressively degrade in the inflammatory environment, leading to gradually release of Exos. Exos are subsequently endocytosed by chondrocytes. ADAMTS4 expression is inhibited by over-expression of miR-99a-3b, promoting the repair of osteoarthritis. miR-99a-3p: microRNA-99 b-3p; ADAMTS4: ADAM Metallopeptidase with Thrombospondin Type 1 Motif 4; ACAN: aggrecan; COMP: cartilage Oligomeric Matrix Protein.