Table 3.
Time-dependent Cox regression analysis of metabolic syndrome according to double occupational exposure after adjusting for all demographic and behavioral risk factors
| Risk factor A | Risk factor B | Exposure number (%) |
HR (95% CI) |
RERI | MI | ||||
|---|---|---|---|---|---|---|---|---|---|
| A | B | A&B | A | B | A&B | ||||
| Night shift work | Noise | 16,264 (17.49) | 6523 (7.01) | 2499 (2.69) | 1.42 (1.33, 1.53) | 1.10 (1.01, 1.20) | 1.66 (1.45, 1.90) | 0.13 | 1.06 |
| Night shift work | Toluene | 18,606 (20.01) | 1025 (1.1) | 157 (0.17) | 1.45 (1.36, 1.54) | 1.41 (1.15, 1.72) | 2.43 (1.55, 3.81) | 0.58 | 1.20 |
| Night shift work | Xylene | 18,671 (20.08) | 400 (0.43) | 92 (0.1) | 1.45 (1.36, 1.54) | 1.71 (1.28, 2.27) | 2.14 (1.18, 3.87) | -0.02 | 0.87 |
| Night shift work | Dichloromethane | 18,659 (20.06) | 539 (0.58) | 104 (0.11) | 1.45 (1.36, 1.55) | 1.53 (1.19, 1.97) | 1.38 (0.73, 2.61) | -0.61 | 0.62 |
| Night shift work | Trichloroethylene | 18,760 (20.17) | 313 (0.34) | 3 (0) | 1.45 (1.36, 1.55) | 1.92 (1.42, 2.61) | 17.19 (1.53, 192.73) | 14.81 | 6.15 |
| Night shift work | Dimethylformamide | 18,756 (20.17) | 210 (0.23) | 7 (0.01) | 1.45 (1.36, 1.54) | 2.15 (1.28, 3.61) | 10.71 (1.45, 79.00) | 8.11 | 3.44 |
| Night shift work | Fe | 18,511 (19.91) | 1113 (1.2) | 252 (0.27) | 1.46 (1.37, 1.56) | 1.39 (1.16, 1.65) | 1.18 (0.75, 1.85) | -0.67 | 0.58 |
| Night shift work | Mn | 18,637 (20.04) | 713 (0.77) | 126 (0.14) | 1.45 (1.36, 1.55) | 1.27 (1.01, 1.59) | 1.73 (1.01, 2.97) | 0.01 | 0.94 |
| Night shift work | Pb | 18,707 (20.12) | 389 (0.42) | 56 (0.06) | 1.44 (1.35, 1.54) | 1.23 (0.86, 1.76) | 3.33 (2.03, 5.47) | 1.66 | 1.88∗ |
| Night shift work | Cu | 18,623 (20.03) | 299 (0.32) | 140 (0.15) | 1.45 (1.36, 1.55) | 2.10 (1.61, 2.74) | 1.76 (1.08, 2.87) | -0.79 | 0.58 |
| Night shift work | Sb | 18,752 (20.16) | 129 (0.14) | 11 (0.01) | 1.45 (1.36, 1.54) | 1.77 (1.00, 3.12) | 3.48 (0.98, 12.37) | 1.27 | 1.36 |
| Noise | Toluene | 8868 (9.54) | 1028 (1.11) | 154 (0.17) | 1.15 (1.07, 1.24) | 1.42 (1.16, 1.74) | 1.65 (1.05, 2.59) | 0.08 | 1.01 |
| Noise | Xylene | 8937 (9.61) | 407 (0.44) | 85 (0.09) | 1.15 (1.07, 1.24) | 1.67 (1.26, 2.22) | 1.85 (1.02, 3.36) | 0.03 | 0.97 |
| Noise | Styrene | 8992 (9.67) | 154 (0.17) | 30 (0.03) | 1.15 (1.07, 1.24) | 1.51 (0.98, 2.31) | 1.75 (0.69, 4.42) | 0.09 | 1.00 |
| Noise | Trichloroethylene | 8995 (9.67) | 289 (0.31) | 27 (0.03) | 1.15 (1.07, 1.24) | 1.85 (1.35, 2.53) | 2.59 (1.02, 6.57) | 0.59 | 1.22 |
| Noise | Fe | 8508 (9.15) | 851 (0.92) | 514 (0.55) | 1.14 (1.06, 1.23) | 1.23 (0.99, 1.52) | 1.42 (1.10, 1.83) | 0.05 | 1.01 |
| Noise | Mn | 8691 (9.35) | 508 (0.55) | 331 (0.36) | 1.15 (1.07, 1.25) | 1.30 (1.00, 1.70) | 1.22 (0.87, 1.70) | -0.24 | 0.81 |
| Noise | Pb | 8904 (9.57) | 327 (0.35) | 118 (0.13) | 1.15 (1.07, 1.24) | 1.51 (1.06, 2.14) | 1.19 (0.68, 2.09) | -0.47 | 0.68 |
| Noise | Cu | 8895 (9.57) | 312 (0.34) | 127 (0.14) | 1.15 (1.06, 1.24) | 1.91 (1.44, 2.54) | 1.89 (1.24, 2.88) | -0.17 | 0.86 |
| Noise | Sb | 8973 (9.65) | 91 (0.1) | 49 (0.05) | 1.15 (1.07, 1.24) | 1.65 (0.81, 3.34) | 2.19 (0.96, 4.99) | 0.39 | 1.16 |
| Toluene | Xylene | 802 (0.86) | 112 (0.12) | 380 (0.41) | 1.28 (1.00, 1.64) | 1.72 (0.92, 3.21) | 1.66 (1.26, 2.19) | -0.34 | 0.75 |
| Toluene | Styrene | 1090 (1.17) | 92 (0.1) | 92 (0.1) | 1.37 (1.12, 1.67) | 1.12 (0.59, 2.14) | 1.91 (1.19, 3.07) | 0.42 | 1.24 |
| Toluene | Cu | 1062 (1.14) | 319 (0.34) | 120 (0.13) | 1.38 (1.12, 1.68) | 1.90 (1.44, 2.50) | 1.83 (1.15, 2.91) | -0.45 | 0.70 |
| Toluene | Sb | 1174 (1.26) | 132 (0.14) | 8 (0.01) | 1.42 (1.18, 1.71) | 1.83 (1.04, 3.23) | 1.94 (0.58, 6.54) | -0.31 | 0.75 |
| Xylene | Styrene | 414 (0.45) | 106 (0.11) | 78 (0.08) | 1.58 (1.17, 2.12) | 1.10 (0.59, 2.04) | 2.05 (1.27, 3.32) | 0.38 | 1.18 |
| Xylene | Fe | 460 (0.49) | 1333 (1.43) | 32 (0.03) | 1.60 (1.23, 2.10) | 1.25 (1.06, 1.48) | 3.00 (1.20, 7.53) | 1.15 | 1.50 |
| Xylene | Pb | 466 (0.5) | 419 (0.45) | 26 (0.03) | 1.65 (1.26, 2.15) | 1.34 (0.97, 1.84) | 2.10 (0.79, 5.58) | 0.12 | 0.95 |
| Xylene | Cu | 362 (0.39) | 309 (0.33) | 130 (0.14) | 1.60 (1.17, 2.19) | 1.88 (1.42, 2.49) | 1.86 (1.19, 2.90) | -0.62 | 0.62 |
| Styrene | Pb | 164 (0.18) | 425 (0.46) | 20 (0.02) | 1.34 (0.87, 2.07) | 1.28 (0.93, 1.76) | 3.27 (1.36, 7.84) | 1.64 | 1.90 |
| Styrene | Cu | 130 (0.14) | 385 (0.41) | 54 (0.06) | 1.10 (0.64, 1.91) | 1.77 (1.36, 2.29) | 2.61 (1.52, 4.49) | 0.74 | 1.34 |
| Styrene | Sb | 182 (0.2) | 138 (0.15) | 2 (0) | 1.47 (0.99, 2.17) | 1.74 (1.01, 2.99) | 13.42 (1.44, 124.94) | 11.22 | 5.27 |
| Dichloromethane | Trichloroethylene | 533 (0 .57) | 206 (0.22) | 110 (0.12) | 1.37 (1.05, 1.80) | 2.06 (1.42, 2.99) | 1.58 (0.98, 2.55) | -0.85 | 0.56 |
| Dichloromethane | Cu | 616 (0.66) | 412 (0.44) | 27 (0.03) | 1.39 (1.09, 1.77) | 1.86 (1.46, 2.37) | 2.19 (0.76, 6.32) | -0.06 | 0.85 |
| Trichloroethylene | Cu | 309 (0.33) | 432 (0.46) | 7 (0.01) | 1.81 (1.33, 2.45) | 1.83 (1.44, 2.33) | 9.59 (2.04, 45.05) | 6.95 | 2.90 |
| Fe | Mn | 605 (0.65) | 79 (0.08) | 760 (0.82) | 1.27 (0.99, 1.62) | 0.78 (0.28, 2.15) | 1.28 (1.03, 1.59) | 0.23 | 1.30 |
| Fe | Cu | 1328 (1.43) | 402 (0.43) | 37 (0.04) | 1.25 (1.06, 1.48) | 1.82 (1.42, 2.35) | 2.44 (1.13, 5.31) | 0.37 | 1.07 |
| Fe | Sb | 1322 (1.42) | 97 (0.1) | 43 (0.05) | 1.25 (1.06, 1.48) | 1.68 (0.91, 3.11) | 2.11 (0.86, 5.22) | 0.18 | 1.00 |
| Mn | Cu | 809 (0.87) | 409 (0.44) | 30 (0.03) | 1.21 (0.97, 1.50) | 1.83 (1.43, 2.35) | 2.44 (1.04, 5.72) | 0.40 | 1.10 |
| Mn | Sb | 834 (0.9) | 135 (0.15) | 5 (0.01) | 1.23 (1.00, 1.52) | 1.74 (1.02, 2.98) | 11.53 (2.50, 53.12) | 9.56 | 5.38∗ |
| Pb | Cu | 400 (0.43) | 394 (0.42) | 45 (0.05) | 1.27 (0.91, 1.77) | 1.83 (1.42, 2.36) | 2.27 (1.13, 4.58) | 0.17 | 0.98 |
Relative excess risk due to interaction (RERI) = HR11 - HR10 - HR01 + 1.
MI (multiplicative effect) = HR11/(HR01 × HR10); HR, Hazard ratio; CI, confidence interval.
∗ Refers to the value of statistical significance (p < 0.05).